Protein Translation

Eric Jan (Autor)

Buch | Softcover

93 Seiten

2014
Morgan & Claypool Publishers (Verlag)
978-1-61504-630-0 (ISBN)

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Protein synthesis is a fundamental aspect of gene expression across kingdoms. The regulation of translation is important for many biological processes including cell fate determination, development, and growth and is especially crucial to maintain cellular homeostasis during cellular stress and virus infection. Misregulation of protein translation can contribute to diseases such as diabetes, cancer, and neurodegenerative diseases. In this chapter, we highlight the basic understanding of eukaryotic translation and the major regulations that control biological events. We focus on signaling pathways that regulate overall protein synthesis and also mechanisms that control translation of specific mRNAs such as cis-acting elements within the 5' and 3 untranslated regions (UTR). Understanding these mechanisms provide insights into the fundamental gene regulations that may provide new targets for combating disease and virus infections.

Department of Biochemistry and Molecular Biology, University of British Columbia

Introduction
Translational Initiation
Regulation of Cap-dependent Translation
Selective Translation of mRNAs
Concluding Remarks
Acknowledgements
References
Author Biography

Reihe/Serie	Colloquium Lectures on Building Blocks of the Cell
Verlagsort	San Rafael
Sprache	englisch
Maße	191 x 235 mm
Gewicht	333 g
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	1-61504-630-5 / 1615046305
ISBN-13	978-1-61504-630-0 / 9781615046300
Zustand	Neuware