Cell Engineering and Regeneration

Jeffrey M. Gimble, Darja Marolt Presen, Richard O. C. Oreffo, Susanne Wolbank, Heinz Redl (Herausgeber)

Buch | Hardcover

XXVI, 800 Seiten

2020 | 1st ed. 2020
Springer International Publishing (Verlag)
978-3-319-08830-3 (ISBN)

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This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.

Prof. Heinz Redl has served as Director of the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (LBI Trauma), part of the AUVA Research Center, since 1998 and is the founder of Trauma Care Consult, a company intended to promote collaboration with industry. His goals are to improve the diagnostic and therapeutic options available to trauma patients, and to establish new national and international networks – as can be seen in the 2006 launch of the Austrian Cluster for Tissue Regeneration and subsequent creation of the European Institute of Excellence for Tissue Engineering and Regenerative Medicine (Expertissue), which he co-founded.

From the Contents: Sources.- Primary cells.- Chondrocytes.- Muscle cells.- ß-cells.- Schwann cells.- Cell lines for test systems.- Immortalized primary cells.- STEM.- Bone marrow derived.- Placenta derived cells.- Amnion.- in toto.- Placenta / Chorion.- Cord/Wharton cells.- Amniotic fluid cells.

Erscheint lt. Verlag	19.8.2020
Reihe/Serie	Reference Series in Biomedical Engineering
Reihe/Serie	Tissue Engineering and Regeneration
Zusatzinfo	XXVI, 800 p. 86 illus., 81 illus. in color.
Verlagsort	Cham
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Biomedizin
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Adipose Derived Cells • Biophysical Modulation • cell differentiation • cell tracking • Olfactory Mucosa • Primary cells
ISBN-10	3-319-08830-0 / 3319088300
ISBN-13	978-3-319-08830-3 / 9783319088303
Zustand	Neuware