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Biochemistry of Collagen -

Biochemistry of Collagen

Buch | Softcover
536 Seiten
2013 | Softcover reprint of the original 1st ed. 1976
Springer-Verlag New York Inc.
978-1-4757-4604-4 (ISBN)
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Collagen is a fascinating protein not only because of its ubiquitous occurrence in multicellular animals, but also because of its unique chemi­ cal structure. Follow­ ing the consideration of primary and secondary structure of collagen, the three-dimensional arrangement of collagen molecules in the fibrils is covered by Miller in Chapter 3.
Collagen is a fascinating protein not only because of its ubiquitous occurrence in multicellular animals, but also because of its unique chemi­ cal structure. As the predominant constituent in bone, cartilage, skin, tendon, and tooth, it is not surprising that collagen is of interest to anatomists, biochemists, biomedical engineers, cell biologists, dermatolo­ gists, dental surgeons, leather chemists, orthopedic surgeons, physiologists, physicians, zoologists, and a host of others. This book was planned to provide an up-to-date comprehensive survey of all aspects of biochemistry of collagen. The recent discovery of genetically distinct collagens with tissue specificity has opened a new era in collagen biochemistry, and Karl Piez discusses this in the opening chapter on primary structure. In the next chapter, Ramachandran and Rama­ krishnan deal with the molecular structure of collagen, placing special emphasis on the conformational aspects of its polypeptide chains. Follow­ ing the consideration of primary and secondary structure of collagen, the three-dimensional arrangement of collagen molecules in the fibrils is covered by Miller in Chapter 3. Collagen is generally in the insoluble state in the living organism due to the cross-linking of individual molecules, and Tanzer describes the various aspects of this cross-linkage in Chapter 4. The biosynthesis of collagen is discussed in depth by Prockop and his colleagues.

1. Primary Structure.- 2. Molecular Structure.- 3. Molecular Packing in Collagen Fibrils.- 4. Cross-Linking.- 5. Intracellular Steps in the Biosynthesis of Collagen.- 6. Aspects of the Animal Collagenases.- 7. Immunological Studies on Collagen.- 8. Collagen Pathology at the Molecular Level.- 9. Collagen and Cell Differentiation.- 10. Synthetic Polypeptide Models of Collagen: Synthesis and Applications.

Erscheint lt. Verlag 6.2.2013
Zusatzinfo 50 Illustrations, black and white; XV, 536 p. 50 illus.
Verlagsort New York, NY
Sprache englisch
Maße 152 x 229 mm
Themenwelt Medizin / Pharmazie Gesundheitsfachberufe Diätassistenz / Ernährungsberatung
Medizin / Pharmazie Pflege
Medizin / Pharmazie Pharmazie PTA / PKA
Naturwissenschaften Biologie Biochemie
ISBN-10 1-4757-4604-0 / 1475746040
ISBN-13 978-1-4757-4604-4 / 9781475746044
Zustand Neuware
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