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Nucleic Acids in the Gas Phase

Valérie Gabelica (Herausgeber)

Buch | Hardcover

XII, 287 Seiten

2014 | 2014
Springer Berlin (Verlag)
978-3-642-54841-3 (ISBN)

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This book gives physical chemists a broader view of potential biological applications of their techniques for the study of nucleic acids in the gas phase. It provides organic chemists, biophysicists, and pharmacologists with an introduction to new techniques they can use to find the answers to yet unsolved questions. Laboratory sciences have bloomed with a variety of techniques to decipher the properties of the molecules of life. This volume introduces techniques used to investigate the properties of nucleic acids in the absence of solvent. It highlights the specificities pertaining to the studies of nucleic acids, although some of the techniques can similarly be applied to the study of other biomolecules, like proteins. The first part of the book introduces the techniques, from the transfer of nucleic acids to the gas-phase, to their detailed physico-chemical investigation. Each chapter is devoted to a specific molecular property, and illustrates how various approaches (experimental and theoretical) can be combined for the interpretation.
The second part of the book is devoted to applying the gas-phase approaches to solve specific questions related to the biophysics, biochemistry or pharmacology of nucleic acids.

Introduction: Why study Nucleic Acids in vacuo?.- Transferring Nucleic Acids to the Gas Phase.- Structure of Nucleic Acids in the Gas Phase.- Interactions between Nucleic Acid Ions and Electrons and Photons.- Gas-phase Spectroscopy of Nucleic Acids.- Fragmentation Reactions of Nucleic Acid Ions in the Gas Phase.- Characterization of Ribonucleic Acids and their Modifications by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.- Quantification of DNA Damage using Mass Spectrometry Techniques.- Ligand Binding to Nucleic Acids.- MS-based Approaches for Nucleic Acid Structural Determination.

"'Nucleic Acids in the Gas Phase,' edited by Valerie Gabelica, takes on the task of telling the story of how mass spectrometry can reveal important information about these biomolecules, even in a small data format. ... the volume succeeds in its overall goal to expose the reader to the breadth of information that can be gleaned from nucleic acids using mass spectrometry ... . this information advances our understanding and appreciation of nucleic acid structure and function." (Patrick A. Limbach, Journal of The American Society for Mass Spectrometry, Vol. 26, 2015)

Erscheint lt. Verlag	11.8.2014
Reihe/Serie	Physical Chemistry in Action
Zusatzinfo	XII, 287 p. 142 illus., 70 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	592 g
Themenwelt	Naturwissenschaften ► Chemie ► Analytische Chemie
Schlagworte	Electron Attachment • Fragmentation Reactions • Ionizing Radiation Damage • Metal Ions and Nucleic Acids • Nucleic Acids Ligand Binding • Nucleic Acids Mass Spectrometry • Nucleic Acids Spectroscopy • RNA/DNA • RNA Sequencing
ISBN-10	3-642-54841-5 / 3642548415
ISBN-13	978-3-642-54841-3 / 9783642548413
Zustand	Neuware