Characterization of Compounds in Solution

Theory and Practice

William H. Streng (Autor)

Buch | Hardcover

273 Seiten

2001
Kluwer Academic/Plenum Publishers (Verlag)
978-0-306-46595-6 (ISBN)

Artikel merken

Scientists from many disciplines require making observations which are dependent upon the behavior of compounds in solution. This ranges from areas in geography, such as oceanography, to areas in chemistry, such as chromatography, to areas in biology, such as pharmacology. Historically, information would be obtained by observing a response for a given set of conditions and then the conditions would be changed and a new response obtained. In this approach there would be little effort made to actually understand how a compound was behaving in solution but rather just the response was noted. Understanding the behavior of compounds in solution is critical to understanding their behavior in biological systems. This has become increasingly important during the last twenty years as an understanding of the biochemistry related to human illness has become better understood. The development of the pharmaceutical industry and the need to rapidly screen large numbers of compounds has made scientists in the area of drug development aware that the pharmacological activity of compounds can be predicted by knowing their solution physical chemical properties. This is not to say that a specific drug-active site interaction can be predicted but rather a prediction can be made whether or not a compound will be absorbed, transported, or distributed within a physiological system in such a way that an interaction can occur.

Compound Characterization.- Thermodynamics.- Kinetics.- Equilibrium Constants.- Partition Coefficient.- Solubility.- Aqueous Solubility of Weak Acids and Bases.- Solution Stability.- Instrumentation.- Equilibria: Experimental Procedures and Examples.- Partitioning: Experimental Procedures and Examples.- Solubility: Experimental Procedures and Examples.- Solution Kinetics: Experimental Procedures and Examples.

Zusatzinfo	XVII, 273 p.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Naturwissenschaften ► Chemie ► Analytische Chemie
ISBN-10	0-306-46595-7 / 0306465957
ISBN-13	978-0-306-46595-6 / 9780306465956
Zustand	Neuware