Impact of Sleep and Sleep Disturbances on Obesity and Cancer (eBook)

Susan Redline, Nathan A. Berger (Herausgeber)

eBook Download: PDF

2013 | 2014
XIII, 239 Seiten
Springer New York (Verlag)
978-1-4614-9527-7 (ISBN)

Infos

Sleep has recently been recognized as a critical determinant of energy balance regulating, restoration and repair of many of the physiologic and psychologic processes involved in modulating energy intake and utilization. In addition to having an impact on obesity, sleep abnormalities, both quantitative and qualitative, have now been shown to have significant effects on obesity associated comorbidities, including metabolic syndrome, premalignant lesions and cancer. Sleep problems and fatigue also constitute a significant challenge for the ever expanding group of cancer survivors. Moreover, circadian misalignment, such as that experienced by 'shift workers' has been shown to be associated with an increased incidence of several malignancies including, breast, colorectal and prostate cancer, consistent with the increasing recognition of the role of clock genes in the metabolic processes. Of increasing concern is the accelerating incidence of sleep disorders in childhood, their association with childhood obesity and associated abnormalities of circulating cytokines, adipokines and metabolic factors, many of which are implicated as etiologic mediators of the connection between obesity and cancer.

Extensive studies have now been initiated to investigate the mechanisms by which disturbances in sleep duration, sleep continuity and sleep related breathing affect circadian rhythm, central and peripheral tissue oxygenation and metabolism, quality and quantity of dietary intake and circulating inflammatory cytokines and regulatory hormones. This volume aims to present the latest research on sleep, sleep disturbance and its correlation to obesity and cancer.

Dr. Susan Redline is the Peter C. Farrell Professor of Sleep Medicine at Harvard Medical School, Senior Physician in the Division of Sleep Medicine at Brigham and Women's Hospital, and Physician in the Division of Pulmonary Medicine at Beth Israel Deaconess Medical Center. Dr. Redline has won several scientific awards for her research in sleep, including the American Thoracic Society's 2012 Recognition Award for Scientific Accomplishments, which recognizes her outstanding scientific contributions in epidemiological research designed to understand the prevention and treatment of sleep disorders.

Dr. Nathan A. Berger is the Hanna-Payne Professor of Experimental Medicine and Director of the Center for Science, Health and Society. He is Professor of Medicine, Biochemistry and Oncology at Case Western Reserve University, School of Medicine. Dr. Berger is a member of many professional societies including the American Society of Hematology, American Society of Biological Chemists, American Society of Clinical Oncology, American Association for Cancer Research, American Society of Clinical Investigation, and the American Association of Physicians. Dr. Berger serves on and chairs many national peer review panels and committees for the National Cancer Institute. He chaired the NCI Scientific Review Group Subcommittee D for Clinical Research Program Project Grant Applications and the NCI/National Center for Complimentary and Alternative Medicine Special Emphasis Review Panel.

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Sleep has recently been recognized as a critical determinant of energy balance regulating, restoration and repair of many of the physiologic and psychologic processes involved in modulating energy intake and utilization. In addition to having an impact on obesity, sleep abnormalities, both quantitative and qualitative, have now been shown to have significant effects on obesity associated comorbidities, including metabolic syndrome, premalignant lesions and cancer. Sleep problems and fatigue also constitute a significant challenge for the ever expanding group of cancer survivors. Moreover, circadian misalignment, such as that experienced by "e;shift workers"e; has been shown to be associated with an increased incidence of several malignancies including, breast, colorectal and prostate cancer, consistent with the increasing recognition of the role of clock genes in the metabolic processes. Of increasing concern is the accelerating incidence of sleep disorders in childhood, their association with childhood obesity and associated abnormalities of circulating cytokines, adipokines and metabolic factors, many of which are implicated as etiologic mediators of the connection between obesity and cancer.Extensive studies have now been initiated to investigate the mechanisms by which disturbances in sleep duration, sleep continuity and sleep related breathing affect circadian rhythm, central and peripheral tissue oxygenation and metabolism, quality and quantity of dietary intake and circulating inflammatory cytokines and regulatory hormones. This volume aims to present the latest research on sleep, sleep disturbance and its correlation to obesity and cancer.

Inhalt

Preface.....Susan Redline and Nathan A. Berger Chapter 1: Sleep Across the Lifespan.....Carolyn Dambrosio and Susan Redline Chapter 2: Effects of Sleep Deficiency on Hormones, Cytokines, and Metabolism.....Orfeu M. Buxton, Josiane L. Broussard, Alexa K. Zahl, Martica Hall Chapter 3: Sleep Disorders and Melatonin.....Katherine A. Dudley and Sanjay R. Patel Chapter 4. Biomedical Effects of Circadian Rhythm Disturbances....Keith C. Summa and Fred W. Turek Chapter 5: Intermittent Hypoxia: Mechanistic Pathways Influencing Cancer.....Jayasri Nanduri and Nanduri. R. Prabhakar Chapter 6: Association of Sleep Apnea and Cancer: From Animal Studies to Human Epidemiological Data.....F. Javier Nieto and Ramon Farré Chapter 7: Shift Work, Obesity, and Cancer.....Elizabeth E. Devore and Eva S. Schernhammer Chapter 8: Sleep Disorders and Cancer Risk.....Cheryl L. Thompson and Li Li Chapter 9: Contribution of Sleep Disturbance to Cancer Fatigue.....Christine Miaskowski and Bradley E. Aouizerat Chapter 10. Sleep Disturbances in Cancer Survivors.....Lavinia Fiorentino and Sonia Ancoli-Israel Chapter 11: Sleep-focused interventions: Investigating the effects of sleep restriction on energy balance.....Marie-Pierre St-Onge and Ari Shechter

Produkt-Details

• Erscheint lt. Verlag: 13.12.2013
• Reihe/Serie: Energy Balance and Cancer
• Reihe/Serie: Energy Balance and Cancer
• Zusatzinfo: XIII, 239 p. 30 illus., 19 illus. in color.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Cancer • Energy balance • gene expression • Obesity • Sleep • Sleep Disorders
• ISBN-10: 1-4614-9527-X / 146149527X
• ISBN-13: 978-1-4614-9527-7 / 9781461495277