Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing

Buch | Softcover

X, 238 Seiten

2014 | 2012
Springer Berlin (Verlag)
978-3-642-42817-3 (ISBN)

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"The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins."

lt;p>ADAR Proteins: Structure and Catalytic Activity.- ADAR Proteins: Double-stranded RNA and Z-DNA Binding Domains.- Editing of Neurotransmitter Receptor and Ion Channel RNAs in the Nervous System.- Modulation of Micro RNA Expression and Function by ADARs.- Nuclear Editing of mRNA 3'-Untranslated Regions.- Control of ADAR1 Editing of Hepatitis Delta Virus RNAs.- Bioinformatic Approaches for Identification of A-to-I Editing Sites.- ADARs, Viruses and Innate Immunity.- Role of ADARs in Mouse Development.- Regulation and Functions of ADAR in Drosophila.- Subject index

Erscheint lt. Verlag	26.1.2014
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	X, 238 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	381 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	ADAR proteins • Innate Immunity • micro RNA function • Neurotransmitter Receptor
ISBN-10	3-642-42817-7 / 3642428177
ISBN-13	978-3-642-42817-3 / 9783642428173
Zustand	Neuware