Enzyme Technologies (eBook)

Pluripotent Players in Discovering Therapeutic Agent

Hsiu-Chiung Yang, Wu-Kuang Yeh, J. R. McCarthy (Autoren)

eBook Download: PDF

2013 | 1. Auflage
356 Seiten
John Wiley & Sons (Verlag)
978-1-118-73989-1 (ISBN)

Infos

Sets the stage for advances in drug discovery using the
latest enzyme technology

Reviewing new and emerging applications of enzyme technology in
drug discovery, this book highlights some of the most promising
areas of pharmaceutical and biotechnology research. It covers
enzyme assay technology, utilization of enzymology for prodrug
design, and the application of enzymes as therapeutic agents.
Expert reviews highlight how our latest understanding of enzymology
is used to develop new practical applications in drug discovery and
design.

Filled with case studies, Enzyme Technologies: Pluripotent
Players in Discovering Therapeutic Agents enables readers to
better understand the diverse functions of enzymes and master
specific applications in drug discovery research. In addition to
small molecule drug discovery, the book explores new developments
in enzymes as therapeutic agents for genetic disorders.

* Section A, Enzymes - Essential Workhorses in
Pharmaceutical Research, offers support in selecting the best
enzyme targets for drug discovery, designing enzyme inhibitors for
therapeutic agents, and evaluating selective enzyme
inhibitors.

* Section B, Enzymes - Indispensable Tools for Improving
Druggability, sets forth the principles alongside real-world
examples of exploiting specific properties of enzymes to design
successful prodrugs.

* Section C, Enzymes - Powerful Weapons for Correcting
Nature's Errors, provides new insights on applying enzymes as
therapeutic agents or diagnostic tools to treat genetic
disorders.

Chapters are contributed by leading experts from around the
world. Their contributions are based on a thorough review of the
current literature as well as their own research.

Reviewing our latest understanding of the nature of enzymes and
their role in drug discovery, this book is recommended for
researchers in pharmaceuticals and biotechnology as well as for
researchers in enzymology, biochemistry, molecular biology, and
medicinal chemistry.

Autor

HSIU-CHIUNG YANG, PhD, is Research Advisor at Eli Lilly and Company. She is the author or coauthor of over forty publications and holder of two patents. WU-KUANG YEH, PhD, is Adjunct Professor at Indiana University Purdue University Indianapolis (IUPUI), and was Director of Research and Principal Investigator at PreClinOmics, Inc. The holder of six U.S. patents, Dr. Yeh is the author or coauthor of over 115 publications. JAMES R. McCARTHY, PhD, is Research Professor in the department of chemistry and chemical biology at Indiana University Purdue University Indianapolis (IUPUI), and was a Distinguished Research Fellow at Eli Lilly and Company. He is the author or coauthor of over 130 publications and holder of over sixty patents.

Inhalt

Contributors vii

Preface ix

Part A _Enzymes - essential workhorses in
pharmaceutical research 1

1 Assay Technologies for Proteases 3

Anuradha Roy, Gerald H. Lushington, James McGee, and Rathnam
Chaguturu

2 Discovery and Development of Isozyme-Selective Inhibitors
Involved in Lipid Metabolism 55

Taichi Ohshiro and Hiroshi Tomoda

3 Covalent Enzyme Inhibition in Drug Discovery and Development
81

Shujaath Mehdi

4 Preclinomics: Enzyme Assays and Rodent Models for Metabolic
diseases 131

Wu-Kuang Yeh and Richard G. Peterson

Part B _Enzymes - indispensable tools for
improving druggability 163

5 Enzymes and Targeted Activation of Prodrugs 165

Yanhui Yang, Yu Chen, Herve Aloysius, Daigo Inoyama, and Longqin
Hu

6 Evolution of an Orally Active Prodrug of Gemcitabine 237

James R. McCarthy

7 Enzymatically Activated Phosphate and Phosphonate Prodrugs
253

Ivan S. Krylov and Charles E. McKenna

Part C E nzymes - powerful weapons for correcting
Nature's errors 301

8 Treatment Options for Mucopolysaccharidosis Type II
(Hunter's Syndrome) 303

Michael Beck

9 Enzyme Replacement Therapy for Fabry Disease 321

Ley Nadine Lacbawan, Wei Zheng, and Ozlem Goker-Alpan

10 Methods and Principles of Pancreatic Function Tests 335

Henrike von Schassen, Jutta Keller, and Peter Layer

Index 341

Rezensionen

"The book serves as a valuable desk reference volume and describes well the key concepts of the standard and emerging enzyme technologies that together constitute some of the fundamental principles and knowledge on which drug discovery research is based." (ChemMedChem, 1 August 2015)

Produkt-Details

• Erscheint lt. Verlag: 22.11.2013
• Reihe/Serie: Chemical Biology of Enzymes for Biotechnology and Pharmaceutical Applications
• Reihe/Serie: Chemical Biology of Enzymes for Biotechnology and Pharmaceutical Applications
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik ► Umwelttechnik / Biotechnologie
• Schlagworte: Biotechnologie • Biotechnologie i. d. Chemie • Biotechnology • Chemie • Chemistry • Drug Discovery & Development • Enzyminhibitor • Pharmaceutical & Medicinal Chemistry • Pharmazeutische u. Medizinische Chemie • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung
• ISBN-10: 1-118-73989-2 / 1118739892
• ISBN-13: 978-1-118-73989-1 / 9781118739891