Immunotoxins
Springer-Verlag New York Inc.
978-1-4612-8419-2 (ISBN)
1. Introduction.- I. Toxin Structure.- 2. Toxin structure.- 3. Structure—activity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A.- II. How Toxins Work.- 4. How protein toxins enter and kill cells.- 5. Mechanism of action of ricin and related toxins on the inactivation of eukaryotic ribosomes.- III. Toxin Selection and Modification.- 6. Toxin selection and modification — Overview.- 7. Toxin selection and modification: Utilization of the A chain of ricin.- 8. Genetic engineering of immunotoxins.- 9. Diphtheria-related peptide hormone gene fusions: A molecular genetic approach to chimeric toxin development.- 10. Immunotoxins containing ricin.- 11. Pseudomonas exotoxin — Immunotoxins.- 12. Immunotoxins containing single chain ribosome-inactivating proteins.- IV. Covalent Linking Agents.- 13. Antibody-toxin conjugation.- 14. Effect of chemical linkage upon the stability and cytotoxic activity of A chain immunotoxins.- V. Antibody Selection.- 15. Immunotoxins: Selection of cell-surface antigens and their corresponding monoclonal antibodies.- VI. Nonantibody Ligands.- 16. Hormone, lectin and toxin-toxin conjugates.- 17. Growth factors and other ligands.- VII. Purification and Chemical Characterization.- 18. Purification and biochemical characterization of immunotoxins.- VIII. Enhancers.- 19. Immunotoxin enhancers.- 20. Enhancement of immunotoxin action: Manipulation of the cellular routing of proteins.- IX. Cytotoxicity.- 21. Methods for quantifying immunotoxin efficacy.- 22. Kinetic analysis of cytotoxicity.- 23. Isolation and analysis of somatic cell mutants resistant to toxin conjugates.- X. Animal Studies.- 24. Immunotoxin therapy: Assessment by animal models.- 25. Prevention of carbohydrate-mediated clearance of ricin-containing immunotoxinsby the liver.- 26. Human immune response to immunotoxins.- XI. Clinical Studies.- 27. Treatment of leukemia patients with T101 ricin A chain immunotoxins.- 28. Clinical studies: Solid tumors.- 29. Immunotoxins for ex vivo bone marrow purging in human bone marrow transplantation.- 30. Conclusion.
Erscheint lt. Verlag | 27.9.2011 |
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Reihe/Serie | Cancer Treatment and Research ; 37 |
Zusatzinfo | XX, 566 p. |
Verlagsort | New York, NY |
Sprache | englisch |
Maße | 160 x 240 mm |
Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Pneumologie |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
Naturwissenschaften ► Biologie ► Biochemie | |
ISBN-10 | 1-4612-8419-8 / 1461284198 |
ISBN-13 | 978-1-4612-8419-2 / 9781461284192 |
Zustand | Neuware |
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