Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Micheline Kirsch-Volders (Autor)

Buch | Softcover

336 Seiten

2011 | Softcover reprint of the original 1st ed. 1984
Springer-Verlag New York Inc.
978-1-4612-9649-2 (ISBN)

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This book is intended for anyone who cares about the health of people exposed to industrial pollutants. Attention is given to those pollutants which present a possible risk to the genetic material of exposed workers. Chapters are devoted to heavy metals such as arsenic, beryllium, cadmium, chromium, lead, mercury, nickel, etc.; insecticides (chlorinated, organophosphorus, and carbonate insecticides); monomers such as vinyl-chloride, acrylonitrile, styrene, vinylidene chloride, butadiene, chlorobutadiene, hexachlorobuta diene, etc.; and halogenated hydrocarbon solvents such as chloroform, carbon tetrachloride, trichloroethylene, I, 2-dichloroethane, tetrachloroethyl ene, dichloromethane, and I, I, I-trichloroethane. The main aim of this work is to provide the physician, the biologist, the pharmacologist, or anyone involved in genetic toxicology with a useful compendium of up-to-date information and references. Efforts are made to open the field to nonspecialists. An introductory chapter deals with the mechanisms whereby a given compound, reaching genetic material, either directly or indirectly, may increase the risk of a cancer developing in the exposed individual and of abnormalities being passed on to his or her progeny. Efforts are also made to allow easy and efficient reading for those who are not interested in detailed results. Comparative tables provide the following data on the compounds studied: chemical properties, production, occurrence, accepted standards in the industry, and positive or negative results with different test systems. Finally, senior research workers might find good descriptions in this book of the most recent results from mutagenesis and carcinogenesis testing in plant, nonmammalian, and mammalian systems.

Introduction: Mutagenesis as a Health Problem.- 1 Molecular Mechanisms of Mutagenesis and Carcinogenesis.- I: Cellular Factors which Modify the Expression of Mutagenic Action Into Genetic Lesions.- II: Relation Between Mutation, Repair, and Chromosome Aberration.- III: Chromosomal Alterations and Carcinogenesis.- References.- 2 Mutagenicity, Carcinogenicity, and Teratogenicity of Industrially Used Metals.- 1. General Considerations.- 2. Arsenic.- 3. Beryllium.- 4. Cadmium.- 5. Chromium.- 6. Lead.- 7. Mercury.- 8. Nickel.- 9. Other Metals.- 10. Conclusions.- References.- 3 Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides.- 1. Introduction.- 2. Chemical and Biochemical Properties.- 3. Mutagenicity.- 4. Carcinogenicity.- 5. Teratogenicity.- 6. Discussion and Conclusions.- References.- 4 Mutagenicity, Carcinogenicity, and Teratogenicity of Industrially Important Monomers.- 1. Introduction.- 2. Vinyl Chloride.- 3. Acrylonitrile.- 4. Styrene.- 5. Vinylidene Chloride.- 6. Butadiene.- 7. Chlorobutadiene.- 8. Hexachlorobutadiene.- 9. General Discussion and Conclusions.- References.- 5 Mutagenicity, Carcinogenicity, and Teratogenicity of Halogenated Hydrocarbon Solvents.- 1. Introduction.- 2. Chloroform.- 3. Carbon Tetrachloride.- 4. Trichlorethylene (TCE).- 5. 1,2-Dichloroethane.- 6. Tetrachloroethylene.- 7. Dichloromethane.- 8. 1-1,1-Trichloroethane.- 9. Conclusions.- References.- Conclusions.

Erscheint lt. Verlag	1.10.2011
Zusatzinfo	XIV, 336 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
	Naturwissenschaften ► Biologie
ISBN-10	1-4612-9649-8 / 1461296498
ISBN-13	978-1-4612-9649-2 / 9781461296492
Zustand	Neuware