Microbial Toxins in Foods and Feeds

Cellular and Molecular Modes of Action

V.R. Jr. Dowell, A.E. Pohland, J.L. Richard (Herausgeber)

Buch | Softcover

634 Seiten

2011 | Softcover reprint of the original 1st ed. 1990
Springer-Verlag New York Inc.
978-1-4612-7916-7 (ISBN)

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Although toxigenic fungi have been known since ancient times, modern mycotoxinology probably began with the early work of Joseph Forgacs and his colleagues in the 1950s. This science grew tremendously with the discovery of aflatoxins and aflatoxicoses in the early 1960s, particulorly following the finding of the carcinogenicity of aflatoxins in test animol species. The discovery and identification of new mycotoxins and mycotoxi- coses, development of analytical procedures, attempted measurement of human and animal exposure, evaluation of toxicological effects, estimotiol' of risk due to human exposure, and development of regulatory control programs have been the major research goals over the past 30 years. In recent years there has also been an explosive growth in our knowledge of the metabolites produced by the algae, especially the dinoflagellate-produced toxins, and the transmission of such toxins up ~,e food chain to reef fish and shellfish. This knowledge has been invalualdl' in understanding and controlling human illness resulting from ingestion of seafood.
We are now, for the first time, able to deal with such common seafood-related human diseases as paralytic, neurotoxic and amnesic shellfish and ciguatera poisoning.

UJNR Panel on Toxic Microorganisms.- Bacterial Toxins.- Overview of Bacterial Toxins with a Nonreductionist Approach to the Mode of Action of Botulinal Neurotoxin.- ADP-Ribosylation of Actin by Clostridial Toxins.- Mechanisms of Action, Diagnostic and Rapid Methods of Analysis of Staphylococcus aureus Enterotoxins.- Genetic Analysis of Regulation and Structure of Shiga-Like Toxin I in Escherichia coli.- Characterization of 50-Kilobase Plasmid of Salmonella choleraesuis Strain AH1-S44.- Primary Structure and Conformation of Clostridium botulinum Neurotoxin.- The Escherichia coli/Vibrio cholerae Family of Enterotoxins.- Structure and Function of Clostridium botulinum Derivative Toxin Analyzed with Monoclonal Antibodies.- Rapid Method for Detection of Pathogenic Yersinia enterocolitica and Yersinia pseudotuberculosis Using Enzyme Immunoassay.- Oligodeoxyribonucleotide Probe Specific for the 230 Kilobase Pair Virulence Plasmid in Enteroinvasive Escherichia coli and Shigella.- Usefulness in the Epidemiology of Food Poisoning Cases of Detection of Specific Restriction Endonucleases in Some Serotypes of Salmonella and Yersinia.- Genetics of Thermostable Direct Hemolysin of Vibrio parahaemolyticus.- Genetic Aspects of Clostridium botulinum.- Molecular Structure and Biological Activities of Clostridium botulinum C2 Toxin.- Genetic Studies on Vibrio fluvialis and its Enterotoxins.- Molecular Structure of Clostridium botulinum Progenitor Toxins.- Purification and Characterization of Bacillus cereus Enterotoxin and its Application to Diagnosis.- Mode of Action of Shiga and Shiga-Like Toxins.- Structure and Function of Clostridium perfringens Enterotoxin.- Biochemical Characteristics and Actions of Toxins from Clostridium difficile Isolated from Antibiotic Associated Diarrhea in Japan.- Restriction Enzyme Analysis in the Epidemiology of Listeria monocytogenes.- Molecular Genetic Analysis of Virulence Factors of Shigella flexneri.- Mycotoxins.- Mycotoxins and Mycotoxicoses: Overview.- Interaction of T-2 Toxin with Cell Membranes.- Biotransformation as a Determinant of Species Susceptibility to Aflatoxin B1: In vitro Studies in Rats, Mouse, Monkey, and Human Liver.- The Gaba Receptor and the Action of Tremorgenic Mycotoxins.- Application of Macromolecular Synthesis Measurements in Mycotoxin Toxicity Studies.- Use of Aflatoxin-DNA and Protein Adducts for Human Dosimetry.- Analysis of Aflatoxin B1-DNA Adducts.- Production and Characterization of a Monoclonal Antibody to Tetraacetylnivalenol.- Interaction of Aflatoxin B1 within Specific Gene Sequences.- Immunologic In vivo Detection of Aflatoxin B1-DNA Adducts in Rats and Rainbow Trout.- The Mode of Action of Anthraquinone Mycotoxins on ATP Synthesis in Mitochondria.- Subcellular Distribution and Macromolecular Binding of Aflatoxin in Fetal and Neonatal Rat Liver.- The Immunosuppressive Action of Gliotoxin and Related Epipolythiodioxopiperazines.- Cellular Effects of Cytochalasins.- Selective Antitumor Activity of T-2 Toxin-Antibody Conjugates.- Effects of Cyclopiazonic Acid: Guinea Pig Skeletal Muscle.- Immunoglobulin A Nephropathy as a Manifestation of Vomitoxin (Deoxynivalenol) Immunotoxicity.- Combined Cyclopiazonic Acid and Aflatoxin B1 Effects on Serum Bacteriostasis, Complement Activity, Glycocholic Acid, and Enzymes and Histopathologic Changes in Guinea Pigs.- Mycotoxin-Induced Alterations in Ion Transport Across Cell Membranes.- Biotransformation of Trichothecenes: The Role of Intestinal Microflora in the Metabolism and Toxicity of Trichothecene Mycotoxins.- Deregulation of C-MYC Gene and Modulation of Glucocorticoid Receptor by Aflatoxin B1.- Selective Effects of T-2 Toxin and Ochratoxin A on Immune Functions.- Emestrin, A New Mycotoxin, Introduced Injuries in Various Organs of Mice.- The Molecular Mechanism of Toxicity of Gliotoxin and Related Epipolythiodioxopiperazines.- Activation and Specificity of Aflatoxin B1 Binding on HHCM, A Human Oncogene of Low Efficiency, and Cell Transformation.- Algal Toxins.- Algal Toxins: General Overview.- The Polyether Brevetoxins and Site Five of the Voltage-Sensitive Sodium Channel.- Cellular Mechanisms of Action for Freshwater Cyanobacteria (Blue-Green Algae) Toxins.- New Aspects of Tetrodotoxin.- Polyether Toxins Implicated in Ciguatera and Seafood Poisoning.- The Cellular Mechanism of Action of Maitotoxin ad Ciguatoxin.- Recent Progress in the Chemistry and Toxicology of Paralytic Shellfish Poisoning.- Contributors.- Taxonomic Index.

Zusatzinfo	634 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Sachbuch/Ratgeber ► Natur / Technik ► Garten
	Medizin / Pharmazie ► Gesundheitsfachberufe ► Diätassistenz / Ernährungsberatung
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Botanik
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Ökologie / Naturschutz
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	1-4612-7916-X / 146127916X
ISBN-13	978-1-4612-7916-7 / 9781461279167
Zustand	Neuware