GLUCAGON: Its Role in Physiology and Clinical Medicine

Its Role in Physiology and Clinical Medice

P.P. Foa, J.S. Bajaj, N.L. Foa, L. Bivens (Herausgeber)

Buch | Softcover

793 Seiten

2011 | Softcover reprint of the original 1st ed. 1977
Springer-Verlag New York Inc.
978-1-4612-6368-5 (ISBN)

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The growing interest in glucagon. almost universal among diabetologists. made the decision to hold a satellite symposium immediately after the IX Congress of the International Diabetes Federation easy. indeed almost unavoidable. The climate. the beauty of its uniquely picturesque canals and houseboats. of its lakes and its mountains and above all. the friendliness of its people made the choice of Sri nagar equally easy. Problems of transportation and housing which appeared of Himalayan proportions from thousands of miles away were resolved with deceptive ease: as if the late autumn sun of New Delhi and Sri nagar had melted the snow that already covered many areas of the United States. For this. we thank the Executive Council and the Scientific Program Advisory Committee of the Congress. the Chairman and Co-Chairman of the local committee, Drs. Ali Mohammed Jan and S. N. Ahmed Shah; the Organizing Secretary, Dr. Syed Zahoor Ahmed; the joint Secretary, Dr. M. Y. Alvi; the Secretary of the Scientific Session. S. N. Dhar and the other committee members, Drs. G. Q. Allaqband, Wm. Riberio, Girja Dhar, J. A. Naqashbandi and Messrs. D. P. Zutshi, K. Amla and Ajit Singh. We are deeply grateful to His Excellency Sheikh Abdullah, Chief Minister of Jammu and Kashmir for his interest in the symposium and for the unforgettable hospitality offered in the name of his people. The suggestions, criticism and understanding of many colleagues helped us select topics and speakers for a representative rather than a comprehensive program.

I. Ontogeny of the A Cell and the Morphology of Glucagon Release.- Ontogeny of the Entero-Pancreatic A Cells and of Glucagon Production.- Morphologic Study of Glucagon Release.- II. Biosynthesis, Nature and Sites of Origin of Pancreatic Glucagon and of Glucagon-Like Immunoreactive Materials.- Glucagon Biosynthesis in Anglerfish Islets: Identification of a 4,900 Dalton Metabolic Conversion Intermediate.- High Molecular Weight Glucagons from Avian Islets and Fetal Bovine Pancreas.- Assessment of Glucagon Immunoreactivity in Plasma.- Quantification of Plasma Glucagon Immunoreactive Components in Normal and Hyperglucagonemic States.- Circulating Glucagon Components: Significance in Health and Disease.- Plasma Immunoreactive Glucagon in Depancreatized Animals.- Heterogeneity of Gut Glucagon-Like Immunoreactivity (GLI).- Glucagon-Like Materials in Porcine and Rat Intestinal Mucosa.- Immunoreactive Glucagon in the Salivary Glands of Man and Animal.- Role of the Submaxillary Gland and of the Kidney in the Hyperglucagonemia of Eviscerated Rats.- Glucagon and the Kidney.- III. Secretion of Pancreatic Glucagon.- The Role of Calcium in Glucagon Secretion.- The Versatile Role of Calcium in Glucagon Release.- Interrelationship of Calcium and Somatostatin in the Secretion of Insulin and Glucagon.- Dynamics and Interrelationships of In Vitro Secretion of Glucagon and Insulin.- Effects of Insulin on the Glucagon Release, Glucose Utilization and ATP Content of the Pancreatic A Cells of the Guinea Pig.- Effect of Vasoactive Intestinal Peptide (VIP) and Gastric Inhibitory Peptide (GIP) on Insulin and Glucagon Release by Perifused Newborn Rat Pancreas.- The Role of the Autonomic Nervous System in Glucagon Secretion.- IV. Mode of Action of Glucagon.- Interactions of Hepatocyte Membrane Receptors with Pancreatic and Gut Glucagon.- Glucagon, Insulin and their Hepatic Receptors: An Endocrine Pattern Characterizing Hepatoproliferative Transitions in the Rat.- Reexamination of the Second Messenger Hypothesis of Glucagon and Catecholamine Action in Liver.- Guanyl Nucleotide Regulation of the Liver Glucagon-Sensitive Adenylyl Cyclase System.- A Peptide Inhibitor of Glucagon-Responsive Adenylate Cyclase in Liver.- Modulation of Nuclear Protein Kinase Activity by Glucagon.- Combined Influence of Insulin and Glucagon Upon Hepatocytes in Rats with Liver Loss or Viral Injury.- V. Metabolic Effects and Physiologic Role of Glucagon.- Insulin and Glucagon (Pancreatic and Extrapancreatic) Interactions and the Regulation of Glucose Turnover in Physiology and in the Diabetic State.- Regulation of Hepatic Gluconeogenesis by Glucagon in the Rat.- Hormonal Regulation of Hepatic Protein Metabolism in the Rat In Vivo. Control of Glucagon.- The Role of Glucagon in Amino Acid Homeostasis.- The Roles of Glucagon and Cyclic Adenosine 3?,5?-Monophosphate in the Regulation of Lipid Biosynthesis.- Lowering of Plasma Lipids, the Major Effect of Repeated Glucagon Administration in Rats.- Glucagon and Lipoprotein Regulation in Man.- Metabolic Fuels in the Embryo and the Newborn.- Role of the Insulin/Glucagon Ratio in the Changes of Hepatic Metabolism during Development of the Rat.- Glucose Homeostasis in the Newborn.- VI. Role of Glucagon in Diabetes Mellitus, in Prediabetes and in Other Disease States.- New Concepts in Glucagon Physiology.- The Issues Related to Abnormal A Cell Function in Diabetes Mellitus.- On the Causes and Consequences of Abnormal Glucagon Secretion in Human Diabetes Mellitus.- The Effects of Exogenously Induced Hyperglucagonemia in Insulin-Treated Diabetics.-The Nature of the A Cell Abnormality in Human Diabetes Mellitus.- The Nature of Hyperglucagonemia in Diabetes Mellitus.- Glucagon in Diabetic Coma.- Glucagon Metabolism in Potential Diabetes Mellitus. Studies of Discordant Twins and Patients After Myocardial Infarction.- Tolbutamide: Stimulator and Suppressor of Glucagon Secretion.- Effect of Long Term Sulfonylurea Therapy on Glucagon Levels in Maturity Onset Diabetes Mellitus.- Effect of Chlorpropamide on Basal and Arginine-Stimulated Plasma Levels of Glucagon and Insulin in Diabetic Patients.- Glucagon and Hypertriglyceridemia.- Glucagonomas and Skin Disease.- Plasma GLI in Gastrectomized Patients.- Pancreatic A Cell Function in a Patient with Addison’s Disease.

Zusatzinfo	793 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	Glucagon • Role of Glucagon in Physiology
ISBN-10	1-4612-6368-9 / 1461263689
ISBN-13	978-1-4612-6368-5 / 9781461263685
Zustand	Neuware