Molecular Biology of Mutagens and Carcinogens

Beatrice Singer, D. Grunberger (Autoren)

Buch | Softcover

348 Seiten

2011 | Softcover reprint of the original 1st ed. 1983
Springer-Verlag New York Inc.
978-1-4613-3774-4 (ISBN)

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This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis. It seemed the appro priate time to sit back and summarize the results of several decades of research in laboratories in different countries. We are very grateful to the Rockefeller Foundation for inviting us to formulate and begin writing the book at the Center for International Studies in Bellagio, Italy, where we were Resident Scholars. We are fortunate to have had the assistance of so many colleagues around the world who cheerfully sent original data, figures, and preprints and lis tened patiently to us as we worked out the various conflicting ideas in this fast-moving. field. The names of these scientists are found within the tables, figures, and references. There is one person whose contributions we especially wish to acknowl edge. Professor Heinz Fraenkel-Conrat was present at the inception of this book and throughout the writing encouraged and criticized in apprOximately equal proportion. Finally, his editing and amalgamation of our two styles gave us great comfort. B.S. D.G.

I Introduction.- II Chemicals as Environmental Mutagens and Carcinogens.- III Intrinsic Properties of Nucleic Acids.- A. Introduction 15.- B. Reactions with Water.- C. Reversible Equilibrium Reactions.- D. Fidelity in Nucleic Acid Synthesis.- E. Transcription and Replication of Modified Templates.- IV Reactions of Directly Acting Agents with Nucleic Acids.- A. Introduction.- B. Simple Nonalkylating Agents.- C. Monofunctional Alkylating Agents.- D. Bifunctional Alkylating Agents.- E. Cyclic Alkylating Agents.- F. Vinyl Halides.- G. Alkyl Carbamates.- V Metabolic Activation of Carcinogens and Mutagens.- A. Enzymatic Activation of Polycyclic Aromatic Hydrocarbons.- B. Specific Metabolites of Polycyclic Aromatic Hydrocarbons.- C. Enzymatic Activation of N-Substituted Aromatic Compounds and Resulting Metabolites.- D. Summary.- VI Reactions of Metabolically Activated Carcinogens with Nucleic Aclds.- A. Detection of DNA-Carcinogen Adducts.- B. Polycyclic Aromatic Hydrocarbons.- C. N-Substituted Aromatic Compounds.- D. Naturally Occurring Carcinogens.- VII Conformation of DNA Modified by Bulky Aromatic Carcinogens.- A. Introduction.- B. Methods of Analysis.- C. Conformation of DNA-7,8-Dihydrodiol-9,lO-Oxide-Benzo[a]pyrene Adducts.- D. Conformation of DNA Modified by N-Substituted Aromatic Compounds.- VIII Repair in Mammalian Organs and Cells.- A. Introduction.- B. In Vivo Removal of Alkyl Derivatives.- C. Mechanisms of Repair of Alkyl Derivatives in Eukaryotes.- D. In Vivo Removal of Aromatic Derivatives.- IX Site-Directed Mutagenesis.- Appendix A UV Spectral Characteristics and Acidic Dissociation Constants of Modified Bases, Nucleosides, and Nucleotides.- Appendix B Acid, Neutral, and Basic Spectra of Bases, Nucleosides, Nucleotides, and 55 Modified Derivatives.

Zusatzinfo	XII, 348 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Sachbuch/Ratgeber ► Natur / Technik ► Garten
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Pharmazie
	Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik)
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	1-4613-3774-7 / 1461337747
ISBN-13	978-1-4613-3774-4 / 9781461337744
Zustand	Neuware