Next Generation Sequencing in Cancer Research (eBook)

Volume 1: Decoding the Cancer Genome

Hani Choudhry, Wei Wu (Herausgeber)

eBook Download: PDF

2013 | 2013
XII, 383 Seiten
Springer New York (Verlag)
978-1-4614-7645-0 (ISBN)

Infos

​​​​This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology. 

Inhalt

1.      The evolution of high-throughput sequencing technologies: from Sanger to single molecule sequencing…..Chee-Seng Ku, Yudi Pawitan, Mengchu Wu, Dimitrios H. Roukos, David N. Cooper2.      Next generation sequencing in cancer epigenomics and potential clinical applications….Hong Kiat Ng, Dimitrios H. Roukos, Barry Iacopetta, Chee-Seng Ku3.      Next Generation Sequencing for Cancer Genomics…..Aarti N Desai and Abhay Jere4.      Genomic Landscape of Cancer Metastasis….Arvind Kumar Singla, Chandini Thirukkumaran and Wei Wu5.      Mapping the HIF transcription factor in cancer by ChIP-seq technology…..Johannes Schödel and David R. Mole6.      Application of next-generation sequencing to analysis of TGFβ/SMAD4 targets in ovarian cancer…..Russell Bonneville, Kenneth Nephew, and Victor X. Jin7.      Targeted Sequencing Strategies in Cancer Research…..HoJoon Lee, Billy T. Lau and Hanlee P. Ji8.      Comprehensive genomic alterations in common cancer cell lines revealed by exome-sequencing…..Han Chang, Donald G. Jackson, Paul S. Kayne, Petra B. Ross-Macdonald, Rolf-Peter Ryseck, and Nathan O. Siemers9.      Application of next generation sequencing in RNA biomarker discovery in cancer research…..Stephen P. Fink, and Kishore Guda10.    Understanding the role of long non-coding RNAs in the cancer genome.....Wei Wu and Jennifer A. Chan11.    Identification of piRNAs in HeLa cells by massive parallel sequencing.....Yilu Lu and Yongxin Ma12.    microRNA expression in breast cancer revealed by deep sequencing technology.....Thalia A. Farazi, Carl S. Leonhardt, and Thomas Tuschl13.    RNA-seq in prostate cancer research.....ShanCheng Ren, Min Qu, Yinghao Sun14.    Next-generation sequencing for high-throughput RNA interference screens.....Toby M. Ward, Anna-Maria Jegg, and Elizabeth Iorns15.    Assessment of Mapping and SNP-detection Algorithms for Next Generation Sequencing Data for Cancer Genomics.....Weixin Wang, Feng Xu, Junwen Wang16.    Applications of very low coverage sequencing in cancer genomics ­ copy number, virus detection and survival.....Henry M Wood17.    Tumor phylogenetics in the NGS era: Strategies, challenges and future prospects.....Ayshwarya Subramanian, Stanley Shackney and Russell Schwartz18.    Impact and challenges in assessing tumor purity by next-generation sequencing…..Xiaoping Su, Gabriel G. Malouf, and Francisco J. Esteva

Produkt-Details

• Erscheint lt. Verlag: 4.8.2013
• Zusatzinfo: XII, 383 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Cancer genome • cancer genomics • high throughput sequencing • mRNA • NGS
• ISBN-10: 1-4614-7645-3 / 1461476453
• ISBN-13: 978-1-4614-7645-0 / 9781461476450