Muscarinic Receptors in Airways Diseases

Johan Zaagsma, Herman Meurs, Ad F. Roffel (Herausgeber)

Buch | Softcover

XI, 266 Seiten

2012 | 1. Softcover reprint of the original 1st ed. 2001
Springer Basel (Verlag)
978-3-0348-9532-3 (ISBN)

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What are the different muscarinic acetylcholine receptor subtypes andhow are they distributed in the airways and molecular signallingmechanisms? What is their function in neurogenic and non-neurogeniccontrol of the airways and in inflammatory mechanisms? How is their geneexpression regulated? The great importance of muscarinic acetylcholinereceptors for the pathophysiology and treatment of chronic inflammatoryobstructive airways diseases calls for a comprehensive and integratedoverview of the current knowledge to address such questions, to discussthe role of these receptor subtypes in diseases such as asthma and COPD,and to present novel perspectives on antimuscarinic drug development.The present book is the worthy result of this need. It points outinnovative insights into the hitherto poorly understood role ofpostjunctional muscarinic M2 receptors in airway smooth musclecontraction and sheds some light on the novel concepts of antimuscarinicdrug development, with special reference to the l

Cholinergic and noncholinergic parasympathetic control of airway smooth muscle.- Role of non-neuronal and neuronal acetylcholine in the airways.- Identification, localization and function of muscarinic receptor subtypes in the airways.- Functional roles of postjunctional muscarinic M2 receptors in airway smooth muscle.- Dysfunction of prejunctional muscarinic M2 receptors: role of environmental factors.- Muscarinic receptor-?-adrenoceptor cross-talk in airway smooth muscle.- Gene regulation of muscarinic receptor subtypes.- Muscarinic control of airway mucus secretion.- The role of anticholinergics in asthma and COPD.- Novel perspectives in anticholinergic therapy.

Erscheint lt. Verlag	23.10.2012
Reihe/Serie	Progress in Inflammation Research
Zusatzinfo	XI, 266 p.
Verlagsort	Basel
Sprache	englisch
Maße	155 x 235 mm
Gewicht	438 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	Asthma • Atmen • Diseases • Muscle • pathophysiology • Physiology
ISBN-10	3-0348-9532-1 / 3034895321
ISBN-13	978-3-0348-9532-3 / 9783034895323
Zustand	Neuware