Oxidative Stress in Skeletal Muscle

Reznick, Packer, SEN, Holloszy, Jackson (Herausgeber)

Buch | Softcover

XIII, 345 Seiten

2012 | 1998
Springer Basel (Verlag)
978-3-0348-9844-7 (ISBN)

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Skeletal muscle consumes significant amounts of oxygen, and its oxygen flux increases significantly under conditions of exercise and muscle contraction. This makes the muscle vulnerable to oxidative stress since concomitantly with the increase of oxygen flow there is an increase of free oxygen radicals which are a byproduct of muscle respiration. A number of studies in the last decade have documented the involvement of free oxygen radicals in exercising muscles. The consequences of muscle oxidative stress have resulted mainly in increased muscle protein oxidation, elevation of lipid peroxidation, and depletion of muscle antioxidants. The mechanisms of this oxidative stress are under extensive investigation in laboratories around the world and are topics of the chapters in this volume. This book is intended for professionals who are interested in muscle function, physiology, pathophysiology and well-being, such as therapists, trainers and medical professionals as well as for researchers in the field of muscle physiology.

Free radicals and oxidative damage in biology and medicine: An introduction.- Oxidative metabolism in skeletal muscle.- Strategies to assess oxidative stress.- The course of exercise-induced skeletal muscle fibre injury.- Free radical mechanisms in exercise-related muscle damage.- The effects of exercise, ageing and caloric restriction on protein oxidation and DNA damage in skeletal muscle.- Antioxidant enzyme response to exercise and training in the skeletal muscle.- Glutathione: A key role in skeletal muscle metabolism.- Vitamin E and its effect on skeletal muscle.- Differential susceptibility of skeletal muscle proteins to free radical-induced oxidative damage in vitro.- Oxidative stress and Ca2+ transport in skeletal and cardiac sarcoplasmic reticulum.- Oxidative stress in skeletal muscle atrophy induced by immobilization.- Effect of growth hormone on oxidative stress in immobilized muscles of old animals.- The diaphragm and oxidative stress.- Oxidative damage after ischemia/reperfusion in skeletal muscle.- Oxidative damage in rat skeletal muscle after excessive L-tryptophan and atherogenic diets.- Oxidative stress and muscle wasting of cachexia.- Free radicals and antioxidants in the pathogenesis of alcoholic myopathy.- Drug-induced muscle damage.- Free radicals and diseases of animal muscle.- Therapeutic trials of antioxidants in muscle diseases.

Erscheint lt. Verlag	16.10.2012
Reihe/Serie	Molecular and Cell Biology Updates
Zusatzinfo	XIII, 345 p.
Verlagsort	Basel
Sprache	englisch
Gewicht	627 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie
Schlagworte	Antioxidant • Lipid • Oxidation • Oxidative stress • pathophysiology • Physiology • Protein • respiration • Skeletal muscle
ISBN-10	3-0348-9844-4 / 3034898444
ISBN-13	978-3-0348-9844-7 / 9783034898447
Zustand	Neuware