Inflammatory Processes:

Molecular Mechanisms and Therapeutic Opportunities

L. Gordon Letts, Douglas W. Morgan (Herausgeber)

Buch | Softcover

XI, 144 Seiten

2012 | 1. Softcover reprint of the original 1st ed. 2000
Springer Basel (Verlag)
978-3-0348-9580-4 (ISBN)

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In November 1998 many of the key leaders of new drug discovery forinflammatory diseases gathered at Hershey, Pennsylvania for the 9thInternational Conference of the Inflammation Research Association. TheConference was held over a five day period and provided a stimulatingenvironment for the open exchange of important advances in basicinflammation research as well as new drug discovery and development.This book encompasses some of the highlights of several presentationsmade at the Conference. It contains some of the latest and importantdevelopments in the field of inflammation research.Topics include the status of eotaxin and chemokines in asthma andallergy, signal transduction and regulation of diverse mediators such asthe JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well asregulators of AP-1, macrophage metalloproteinases, lymphotoxin andfurther insights into the role of MCP-1 in disease. Also discussed aredrug targets in rheumatoid and osteoarthritis, fibrotic diseases,...

The role of eotaxin and related CC-chemokines in asthma and allergy.- Signal transduction by the JNK group of MAP kinases.- Cellular signaling to NF-?B: Role in inflammation and therapeutic promise.- Small molecule regulators of AP-1 and NF-?B.- Mammalian target of rapamycin: Immunosuppressive drugs offer new insights into cell growth regulation.- Constitutive expression of a tumor suppressor leads to tumor regression in a xenograft model.- Macrophage metalloproteinases in destructive inflammatory diseases.- Lymphotoxin in inflammation and lymphoid organ development: Variations on a theme.- Chemokine/cytokine biology during the evolution of fibrotic disease.- The role of MCP-1 in disease.- The role of chemokines in allergic diseases of the airways.- Ninth International Conference of the Inflammation Research Association, November 1-5, 1998: Summaries of workshops and poster discussions.- Targets in rheumatoid and osteoarthritis.- Signal transduction and regulation of gene expression.- Mediators of inflammation and their enzymes.- Cell adhesion molecules and leukocyte trafficking.- Pulmonary inflammation, fibrosis, and disease.- Angiogenesis, wound repair and skin inflammation.

Erscheint lt. Verlag	29.10.2012
Reihe/Serie	Progress in Inflammation Research
Zusatzinfo	XI, 144 p.
Verlagsort	Basel
Sprache	englisch
Maße	155 x 235 mm
Gewicht	254 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	Asthma • Chemokine • gene expression • Molecular mechanisms • Regulation • signal transduction
ISBN-10	3-0348-9580-1 / 3034895801
ISBN-13	978-3-0348-9580-4 / 9783034895804
Zustand	Neuware