Transition Metal-Catalyzed Couplings in Process Chemistry (eBook)
401 Seiten
Wiley-VCH (Verlag)
978-3-527-65892-3 (ISBN)
book through case studies in which process chemists from the pharmaceutical industry share their personal experiences developing their own transition metal-catalyzed couplings for the large-scale manufacture of active pharmaceutical ingredients.
Authors from Pfizer, Merck, Boehringer-Ingelheim, Novartis, Amgen, GSK, AstraZeneca, and other companies describe the evolution of robust coupling processes from inception through early and late development, including commercial routes where applicable. This book covers a wide range of coupling transformations while capturing the lessons learned from each process. Every case study details the optimization of at least one transition metal-catalyzed coupling while elaborating on issues such as design of experiments, scalability and throughput, product purification, process safety, and waste management. The important issue of metal removal and the different technologies available to accomplish this goal are also addressed. Finally, a section covers novel technologies for cross-coupling with high potential for future applications on a large scale, such as microwave and flow chemistry as well as green cross-couplings performed in water.
With Forewords by Stephen L. Buchwald, Massachusetts Institute of Technology, Trevor Laird, Editor of Organic Process Research and Development and Neal G. Anderson, Anderson's Process Solutions LLC.
Javier Magano was born in Madrid, Spain. He received a B.S. in organic chemistry from Complutense University in Madrid in 1987 and a M.Sc. degree in chemistry from the University of Michigan in 1990. After working for the oil industry in Spain for several years, he obtained a M.Sc. degree in rubber and polymer science at the Center for Advanced Scientific Research in Madrid. After moving back to the United States, he joined the early process chemistry group at Pfizer in 1998 in Ann Arbor, MI, where he spent nine years developing scalable processes for the preparation of drug candidates. In 2007, he moved to Groton, CT to continue his work as a process chemist and, during this period, he has also worked in the area of biologics for 1.5 years on the preparation of linkers for bioconjugation processes. Javier currently holds a position in the Chemical Technology group at Pfizer, where he is involved in the applications of high-throughput screening to transition metal-catalyzed couplings. His research interests also include the development of catalytic processes that employ non-precious metals in coupling reactions. Joshua R. Dunetz graduated from Haverford College in 2000 with a B.A. in Chemistry after undergraduate research with Professor Karin Åkerfeldt. He received his Ph.D. in Organic Chemistry from MIT in 2005 under the guidance of Professor Rick Danheiser, and then completed postdoctoral studies with Professor William Roush at Scripps Florida. In early 2008, Joshua assumed his current position with Pfizer Chemical R&D in which he develops processes for the GMP manufacture of small molecules on gram to multikilogram scale.
FOREWORD 1
FOREWORD 2
FOREWORD 3
INTRODUCTION
COPPER-CATALYZED COUPLING FOR A GREEN PROCESS
Introduction
Synthesis of Amino Acid 14
Copper-Catalyzed Cyclization
Sustainability
Summary
EXPERIENCES WITH NEGISHI COUPLINGS ON TECHNICAL SCALE IN EARLY DEVELOPMENT
Introduction
Synthesis of LBT613 via Pd-Catalyzed Negishi Coupling
Elaboration of a Negishi Coupling in the Synthesis of PDE472
Ni-Catalyzed Negishi Coupling with Catalytic Amounts of ZnCl2
Conclusions
DEVELOPING PALLADIUM-CATALYZED ARYLATIONS OF CARBONYL-ACTIVATED C - H BONDS
Introduction
Suzuki Approach to Side Chain Installation
Arylation of Carbonyl-Activated C - H Bonds
Pd Purging from API
Conclusions
DEVELOPMENT OF A PRACTICAL SYNTHESIS OF NAPHTHYRIDONE P38 MAP KINASE INHIBITOR MK-0913
Introduction
Medicinal Chemistry Approach to 1
Results and Discussion
Conclusions
PRACTICAL SYNTHESIS OF A CATHEPSIN S INHIBITOR
Introduction
Synthetic Strategy
Syntheses of Building Blocks
Sonogashira Coupling and Initial Purification of 1
Salt Selection
Conclusions
C - N COUPLING CHEMISTRY AS A MEANS TO ACHIEVE A COMPLICATED MOLECULAR ARCHITECTURE: THE AR-A2 CASE STORY
A Novel Chemical Entity
Evaluation of Synthetic Pathways: Finding the Best Route
Enabling C - N Coupling by Defining the Reaction Space
From Synthesis to Process
Concluding Remarks
PROCESS DEVELOPMENT AND SCALE-UP OF PF-03941275, A NOVEL ANTIBIOTIC
Introduction
Medicinal Chemistry Synthesis of PF-03941275
Synthesis of 5-Bromo-2,4-difluorobenzaldehyde (1)
Synthesis of Amine 3
Miyaura Borylation Reaction
Suzuki - Miyaura Coupling
Barbituric Acid Coupling
Chlorination and API Isolation
Conclusions
DEVELOPMENT OF A PRACTICAL NEGISHI COUPLING PROCESS FOR THE MANUFACTURING OF BILB 1941, AN HCV POLYMERASE INHIBITOR
Introduction and Background
Stille Coupling
Suzuki Coupling
Negishi Coupling
Comparison of Three Coupling Processes
APPLICATION OF A RHODIUM-CATALYZED, ASYMMETRIC 1,4-ADDITION TO THE KILOGRAM-SCALE MANUFACTURE OF A PHARMACEUTICAL INTERMEDIATE
Introduction
Early Development
Process Optimization
Process Scale-up
Recent Developments
Conclusions
COPPER-CATALYZED C - N COUPLING ON LARGE SCALE: AN INDUSTRIAL CASE STUDY
Introduction
Process Development of the C - N Bond Formation
Choice of Catalytic System
Choice of Base: Inorganic Versus Organic
Choice of Solvent
Optimized Conditions for C - N Bond Formation to 1
Purging Residual Copper from 1
Conclusions
DEVELOPMENT OF A HIGHLY EFFICIENT REGIO- AND STEREOSELECTIVE HECK REACTION FOR THE LARGE-SCALE MANUFACTURE OF AN A4B2 NNR AGONIST
Introduction
Process Optimization
Conclusions
COMMERCIAL DEVELOPMENT OF AXITINIB (AG-013736): OPTIMIZATION OF A CONVERGENT PD-CATALYZED COUPLING ASSEMBLY AND SOLID FORM CHALLENGES
Introduction
First-Generation Synthesis of Axitinib
Early Process Research and Development
Commercial Route Development
Conclusions
LARGE-SCALE SONOGASHIRA COUPLING FOR THE SYNTHESIS OF AN MGLUR5 NEGATIVE ALLOSTERIC MODULATOR
Introduction
Background
Process Development of the Sonogashira Coupling
Large-Scale Sonogashira Coupling and API Purification
Conclusions
PALLADIUM-CATALYZED BISALLYLATION OF ERYTHROMYCIN DERIVATIVES
Introduction
Discovery of 6,11-O,O-Bisallylation of Erythromycin Derivatives
Process Development of 6,11-O,O-Bisallylation of Erythromycin Derivatives
Discovery and Optimization of 3,6-Bicyclolides
Conclusions
ROUTE SELECTION AND PROCESS DEVELOPMENT FOR THE VANILLOID RECEPTOR-1 ANTAGONIST AMG 517
Introduction
Retrosynthesis and Medicinal Chemistry Route
Optimization of Medicinal Chemistry Route
Identification of the Process Chemistry Route
Optimization of the Suzuki - Miyaura Reaction
Postcampaign Improvements
Summary
TRANSITION METAL-CATALYZED COUPLING REACTIONS IN THE SYNTHESIS OF TARANABANT: FROM INCEPTION TO PILOT IMPLEMENTATION
Introduction
Development of Pd-Catalyzed Cyanations
Development of Pd-Catalyzed Amidation Reactions
Conclusio
Erscheint lt. Verlag | 3.7.2013 |
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Sprache | englisch |
Themenwelt | Naturwissenschaften ► Chemie |
Technik | |
Schlagworte | Chemie • Chemistry • Industrial Chemistry • Industrielle Chemie • Methods - Synthesis & Techniques • Organische Chemie / Methoden, Synthesen, Verfahren • Pharmaceutical & Medicinal Chemistry • Pharmazeutische Chemie • Pharmazeutische Industrie • Pharmazeutische u. Medizinische Chemie • Technische u. Industrielle Chemie |
ISBN-10 | 3-527-65892-0 / 3527658920 |
ISBN-13 | 978-3-527-65892-3 / 9783527658923 |
Haben Sie eine Frage zum Produkt? |
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