Gadd45 Stress Sensor Genes

Dan A. Liebermann, Barbara Hoffman (Herausgeber)

Buch | Hardcover

134 Seiten

2013 | 2013 ed.
Springer-Verlag New York Inc.
978-1-4614-8288-8 (ISBN)

Infos

Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  

Inhalt

Gadd45 in stress signaling, cell cycle control and apoptosis.- Gadd45 in Modulation of Solid Tumors and Leukemia.- Gadd45 Proteins: Key players of repair-mediated DNA demethylation.- Gadd45 proteins in Immunity.- Gadd45 in the liver — Signal transduction and transcriptional mechanisms.- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics.- Gadd45 stress sensors in preeclampsia.- Index.

Produkt-Details

• Erscheint lt. Verlag: 9.10.2013
• Reihe/Serie: Advances in Experimental Medicine and Biology ; 793
• Zusatzinfo: 11 Illustrations, color; 7 Illustrations, black and white; X, 134 p. 18 illus., 11 illus. in color.
• Verlagsort: New York, NY
• Sprache: englisch
• Maße: 155 x 235 mm
• Gewicht: 3435 g
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Schlagworte: gadd45 genes • Gene function • proteins • stress sensors • stress signaling
• ISBN-10: 1-4614-8288-7 / 1461482887
• ISBN-13: 978-1-4614-8288-8 / 9781461482888
• Zustand: Neuware