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Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

Larry J. Anderson, Barney S. Graham (Herausgeber)

Buch | Hardcover

XI, 409 Seiten

2014 | 2014
Springer Berlin (Verlag)
978-3-642-38918-4 (ISBN)

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Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.

Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease.- Clinical and Epidemiologic Features of Respiratory Syncytial Virus.- Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immunity.- Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins.- Respiratory Syncytial Virus and Reactive Airway Disease.- Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches.- Innate Immune Responses to Respiratory Syncytial Virus Infection.- The Adaptive Immune Response to Respiratory Syncytial Virus.- Respiratory Syncytial Virus Mechanisms to Interfere with Type 1 Interferons.- Host Gene Expression and Respiratory Syncytial Virus Infection.- Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus.- Respiratory Syncytial Virus Disease: Prevention and Treatment.- Live-Attenuated Respiratory Syncytial Virus Vaccines.- Subunit and Virus-Like Particle Vaccine Approaches for Respiratory Syncytial Virus.- Gene-Based Vaccine Approaches for Respiratory Syncytial Virus.- Bovine Model of Respiratory Syncytial Virus Infection.- The Cotton Rat S. hispidus Model of Respiratory Syncytial Virus Infection.- The Mouse Model of Respiratory Syncytial Virus Disease.- Human Airway Epithelial Cell Cultures for Modeling Respiratory Syncytial Virus Infection.- Challenges and Opportunities for Respiratory Syncytial Virus Vaccines.

From the reviews:

"I enjoyed the book: as an immunologist who has spent 10 years working on RSV there were a number of novel insights and it was nice to see it all in one place. ... I will be recommending it to PhD students and Postdocs starting out on RSV research ... . also recommend it to people who have been working with RSV for a while to dip in and out of to fill any gaps in the general knowledge." (John Tregoning, Immunology News, May, 2014)

Erscheint lt. Verlag	7.1.2014
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XI, 409 p. 38 illus., 22 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	795 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Pneumologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pädiatrie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	epidemiology • Infectious Diseases • pathogenesis • RSV • vaccines • Virology • virus infection
ISBN-10	3-642-38918-X / 364238918X
ISBN-13	978-3-642-38918-4 / 9783642389184
Zustand	Neuware