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Untranslated Gene Regions and Other Non-coding Elements

Regulation of Eukaryotic Gene Expression

Lucy W. Barrett, Sue Fletcher, Steve D. Wilton (Autoren)

Buch | Softcover

VIII, 56 Seiten

2013 | 2013
Springer Basel (Verlag)
978-3-0348-0678-7 (ISBN)

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There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.

Introduction.- Promoter.- 5' Untranslated Region.- Structure.- Intronic Regions.- 3' Untranslated Region.- Non-coding RNAs.- Conclusion.

Erscheint lt. Verlag	9.7.2013
Reihe/Serie	SpringerBriefs in Biochemistry and Molecular Biology
Zusatzinfo	VIII, 56 p. 2 illus. in color.
Verlagsort	Basel
Sprache	englisch
Maße	155 x 235 mm
Gewicht	118 g
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Botanik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	DNA regulation • gene expression • Introns • Junk DNA • Non-coding RNA • Promotors
ISBN-10	3-0348-0678-7 / 3034806787
ISBN-13	978-3-0348-0678-7 / 9783034806787
Zustand	Neuware