Blick ins Buch

Gamma-Glutamyl Transpeptidases

Structure and Function

Immacolata Castellano, Antonello Merlino (Autoren)

Buch | Softcover

VIII, 57 Seiten

2013 | 2013
Springer Basel (Verlag)
978-3-0348-0681-7 (ISBN)

Lese- und Medienproben

Blick ins Buch (midvox)

Artikel merken

Gamma-Glutamyl Transpeptidases (Gamma-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the Gamma-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released Gamma-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). Gamma-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.Gamma-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson's disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of Gamma-GTs and gives information about applications of Gamma-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.

1 Introduction.- 2 Occurrence, genes and gene expression.- 3 Structure and function of Gamma-GTs.- 4 Autoprocessing and reaction mechanism of Gamma-GTs.- 5 Gamma-GT in bioclinical.- 6 Gamma-GTs: biotechnological and biomedical applications.- 7 Conclusions.- References.

Erscheint lt. Verlag	25.7.2013
Reihe/Serie	SpringerBriefs in Biochemistry and Molecular Biology
Zusatzinfo	VIII, 57 p. 28 illus., 18 illus. in color.
Verlagsort	Basel
Sprache	englisch
Maße	155 x 235 mm
Gewicht	124 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Technik ► Umwelttechnik / Biotechnologie
Schlagworte	biochemical engineering • Cellular redox homeostasis • enzymes • Glutathione metabolism • inflammation • Oxidative stress • Transferases
ISBN-10	3-0348-0681-7 / 3034806817
ISBN-13	978-3-0348-0681-7 / 9783034806817
Zustand	Neuware