AIDS Pathogenesis

H. Schuitemaker, Frank Miedema (Herausgeber)

Buch | Hardcover

284 Seiten

2000
Springer (Verlag)
978-0-7923-6196-1 (ISBN)

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Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment.

Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS).
The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.

Aids Pathogenesis: Table of Contents.- 1 HIV-1 transmission.- 2 Primary HIV infection.- 3 Biological variability of HIV-1.- 4 T-cell dynamics and renewal in HIV-1 infection.- 5 Long-term non-progressive HIV infection.- 6 Cytotoxic T lymphocytes in HIV-1 infection.- 7 Mechanisms and in-vivo significance of HIV-1 neutralisation.- 8 Suppression of primate immunodeficiency lentiretroviruses CD8+ T-cell-derived soluble factors.- 9 Opportunistic infections.- 10 — AIDS-related non-Hodgkin’s lymphomas.- — Pathogenesis of Kaposi’s sarcoma.- 11 AIDS dementia complex.- 12 Anti-retroviral therapy and resistance to anti-retroviral drugs.- 13 Prognostic markers and immunological reconstistution during HIV-1 infection.- 14 HIV-viral load.- 15 — The SCID-hu mouse: an in-vivo model for HIV-1 infection in humans.- — Non-human primate models for HIV-1 infection.

Erscheint lt. Verlag	31.3.2000
Reihe/Serie	Immunology and Medicine ; 28
Zusatzinfo	XII, 284 p.
Verlagsort	Dordrecht
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
ISBN-10	0-7923-6196-2 / 0792361962
ISBN-13	978-0-7923-6196-1 / 9780792361961
Zustand	Neuware