Programmed Alternative Reading of the Genetic Code

Molecular Biology Intelligence Unit

Philip J. Farabaugh (Autor)

Buch | Softcover

208 Seiten

2012 | Softcover reprint of the original 1st ed. 1997
Springer-Verlag New York Inc.
978-1-4613-7748-1 (ISBN)

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2. The Translational Machinery ...5 Translation Initiation in Prokaryotes ...6 Translation Initiation in Eukaryotes ...8 14 Translation Elongation ...Translation Termination in Prokaryotes ...16 Translation Termination in Eukaryotes ...17 Error Correction in Translation ...18 A Structural Basis of Error Correction in Translation ...20 Ribosome Editing: A Failsafe Error Correction Mechanism ...22 Conclusions ...22 3. Errors During Elongation Can Cause Translational 29 Frameshifting ...Spontaneous Frameshifting Versus Programmed Frameshifting ...30 Spontaneous Frameshifts Can Be Induced at Specific Codons ...31 4. Programmed +1 Frameshifting ...41 The pifE Gene of E. coli ...41 Using the pifE System to Study General Frameshifting in E. coli ...46 Ty Retrotransposons in Yeast ...47 Frameshifting in Retrotransposon Ty1 Occurs by tRNA Slippage ...48 Frameshifting in Retrotransposon Ty3 Occurs by Out-of-Frame Binding of tRNA ...51 The Rat Ornithine Decarboxylase Antizyme Gene ...56 Summary ...62 5. Programmed -1 Frameshifting in Eukaryotes ...69 Programmed -1 Frameshifting in Eukaryotes ...69 -1 Frameshifting Occurs on a "Slippery Heptamer" ...71 The Simultaneous-Slippage Model ...7
2 of -1 Frameshifting by a Downstream Pseudoknot ...77 Stimulation Does the Pseudoknot Only Block Passage of the Ribosome? ...79 Not All Pseudoknots Which Cause Ribosomes to Pause Can Stimulate -1 Frameshifting ...84 Is There a Pseudoknot Recognizing Factor? ...88 Some Simultaneous-Slippage Sites Do Not Include a Stimulatory Pseudo knot ...91 Frameshifting Regulates a Morphogenetic Process ...92 6. Programmed -1 Frameshift Sites in Prokaryotes ...103 The dnaXGene: -1 Frameshifting Stimulated by Both Upstream and Downstream Elements ...103 Programmed -1 Frameshifts in Insertion Sequences Are Mechanistically Diverse ...

1. Introduction.- 2. The Translational Machinery.- 3. Errors During Elongation Can Cause Translational Frameshifting.- 4. Programmed +1 Frameshifting.- 5. Programmed ?1 Frameshifting in Eukaryotes.- 6. Programmed ?1 Frameshift Sites in Prokaryotes.- 7. tRNA Hopping.- 8. Programmed Readthrough of Translational Termination Codons.- 9. Programmed Alternative Decoding as Programmed Translational Errors.- 10. Concluding Remarks.

Zusatzinfo	VII, 208 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	1-4613-7748-X / 146137748X
ISBN-13	978-1-4613-7748-1 / 9781461377481
Zustand	Neuware