Biochemistry and Genetics of Recq-Helicases
Seiten
2012
|
Softcover reprint of the original 1st ed. 2001
Springer-Verlag New York Inc.
978-1-4613-5537-3 (ISBN)
Springer-Verlag New York Inc.
978-1-4613-5537-3 (ISBN)
Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms.
Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.
Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.
1: The RecQ-family helicases.- 1. Helicases, topoisomerases, and disease.- 2. The RecQ-family helicases.- 3. Conclusions.- 2: Targeting the WRN locus in the mouse.- Abstract.- 1. Introduction.- 2. Materials and Methods.- 3. Results.- 4. Discussion.- 5. Acknowledgments.- 3: Interaction of the BLM protein with Topo III alpha in somatic and meiotic cells.- Abstract.- 1. Introduction.- 2. Materials and methods.- 3. Results.- 4. Discussion.- 5. Acknowledgments.- 4: Nijmegen breakage syndrome disease protein and Mre11 at PML nuclear bodies and meiotic telomeres.- Abstract.- 1. Introduction.- 2. Materials and methods.- 3. Results.- 4. Discussion.- 5. Acknowledgments.
| Zusatzinfo | XVI, 92 p. |
|---|---|
| Verlagsort | New York, NY |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
| Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik) | |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Biologie ► Evolution | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| ISBN-10 | 1-4613-5537-0 / 1461355370 |
| ISBN-13 | 978-1-4613-5537-3 / 9781461355373 |
| Zustand | Neuware |
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