Molecular Mechanisms of Werner’s Syndrome

Michel Lebel (Autor)

Buch | Softcover

156 Seiten

2012 | Softcover reprint of the original 1st ed. 2004
Springer-Verlag New York Inc.
978-1-4613-4766-8 (ISBN)

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During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a great deal of information that gives some aspects of aging a better understanding. This book explores Werner's syndrome. To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.

1. Clinical Aspects of Werner’s Syndrome: Its Natural History and the Genetics of the Disease.- 2. Biochemical Roles of RecQ Helicases.- 3. Biochemical Characterization of the Werner Syndrome DNA Helicase-Exonuclease.- 4. Proteins That Interact with the Werner Syndrome Gene Product.- 5. Sensitivity of Werner’s Syndrome Cells to DNA Damaging Agents: Insights into the Biological Functions of the Werner Protein.- 6. Yeast RecQHelicases: Clues to DNA Repair, Genome Stability and Aging.- 7. Potential Function of the Werner’s Syndrome Homologue in the African Clawed Frog and the Mouse.- 8. Proposed Biological Functions for the Werner Syndrome Protein in DNA Metabolism.- Replicative Senescence, Telomeres and Werner’s Syndrome.

Zusatzinfo	X, 156 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	156 x 234 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-10	1-4613-4766-1 / 1461347661
ISBN-13	978-1-4613-4766-8 / 9781461347668
Zustand	Neuware