Toxicogenomics (eBook)

A Powerful Tool for Toxicity Assessment

Saura C. Sahu (Autor)

eBook Download: PDF

2008 | 1. Auflage
422 Seiten
John Wiley & Sons (Verlag)
978-0-470-69964-5 (ISBN)

Infos

Toxicogenomics is the integration of genomics to toxicology. This
technology is a powerful tool for collecting information from a
large number of biological samples simultaneously and thus it is
very useful for large-scale screening of potential toxicants.

Toxicogenomics: A Powerful Tool For Toxicity Assessment
provides up-to-date state-of-the-art information presented by the
recognized experts, and is therefore an authoritative source of
current knowledge in this field of research. The potential link
between toxicology, genetics and human diseases makes this book
very useful to investigators in many and varied disciplines of
science and toxicology. Topics covered include:

* mechanistic toxicogenomics

* analysis and interpretation of toxicogenomic data

* principles of data mining in toxicogenomics

* design issues in toxicogenomics studies

* sources of variability in toxicogenomic assays

* Escherichia coli stress response as a tool for detection
of toxicity

* toxicogenomics as a tool to assess immunotoxicity

* toxicogenomics and ecogenomics for studying endocrine
disruption and basic biology

* use of toxicogenomics as an early predictive tool for
hepatotoxicity

* nutrigenomics: the application of genomic signatures in
nutrition-related research

* application of toxicogenomics in drug discovery

* potential uses of toxicogenomic biomarkers in occupational
health and risk assessment

* usefulness of toxicogenomics in the regulatory environment

* perspectives on toxicogenomics at the US Environmental
Protection Agency

Toxicogenomics: A Powerful Tool For Toxicity Assessment
is an essential resource for research scientists currently
engaged in toxicogenomics, and will also be of interest to
researchers working in toxicology, genetics, medicine,
pharmacology, and food sciences, and to regulators and risk
assessors of drug, food, environmental and agricultural
products.

Autor

Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, Dec 2007).

Inhalt

1. Mechanistic toxicogenomics: Design and analysis of microarray
experiments (Kirstin Meyer, Susanne Schwenke and Johanna M.
Beekman).

2. Analysis and interpretation of toxicogenomic data: Biological
responses to low, environmentally-relevant doses of toxicants
(Julia A. Gosse, Jennifer Davey, Thomas Hampton and Joshua
Hamilton).

3. Principles of data-mining in toxicogenomics (Yoko Hirabayashi
and Tohru Inoue).

4. Design issues in toxicogenomics studies: The application of
genomic technologies for mechanistic and predictive research
(Woong-Yang Park, Lian Li and Daehee Kang).

5. Sources of variability in toxicogenomic assays (Karol
Thompson, P. Scott Pine and Barry Rosenzweig).

6. Key aspects of toxicogenomic data analysis and interpretation
as a safety assessment tool to identify and understand drug-induced
toxicity (Antoaneta Vladimirova and Brigitte Ganter).

7. Toxicogenomics as a tool to assess immunotoxicity (Kirsten
Baken, J. Ezendam, J. Pennings, R. Vandebriel,and H. Loveren).

8. Toxicogenomics and ecogenomics for studying endocrine
disruption and basic biology (Taisen Iguchi, Hajime Watanabe and
Yoshino Kata).

9. Gene expression profiling of transplacental arsenic
carcinogenesis in mice (Jie Liu, B. Diwan, R. Tennant and Michael
Waalkes).

10. Characterization of estrogen active compounds and estrogenic
signaling by global gene expression profiling in vitro (Stephanie
Simon, Kathleen Boehme, Susanne Schmidt and Stephan Mueller).

11. Escherichia coli stress response as a tool for detection of
toxicity (Arindam Mitra, Nabarun Chakraborti and Suman
Mukhopadhyay).

12. Toxicogenomics in vitro: A powerful tool for screening
hepatotoxic potential of food-related products (Saura C. Sahu).

13. Toxicogenomics approach to drug-induced phospholipidosis
(Hiroshi Sawada).

14. Use of toxicogenomics as an early predictive tool for
Hepatotoxicity (Laura Suter).

15. Nutrigenomics: The application of genomic signatures in
nutrition-related research (Stamotis Theocharis and Elisavet
Gatzidou).

16. Application of toxicogenomics in drug discovery (Michael
Liguori, Amy Ditewig and Jeffery Waring).

17. Natural products from medicinal plants and risk assessment
(Leila Chekir-Ghedira).

18. The development of a metabonomic-based drug safety testing
paradigm (Muireann Coen, Elaine Holms, Jeremy Nicholson and John
Lindon).

19. Potential Uses of Toxicogenomic Biomarkers in Occupational
Health and Risk Assessment (Paul A. Nony).

20. Usefulness of toxicogenomics in the regulatory environment
(Daniel Casciano).

21. Toxicogenomics for regulatory use: the view from the bench
(P. Ancian, S.Leuillett, S. Artaud, J. Jegard and Roy Forster).

22. Perspectives on toxicogenomics at the US Environmental
Protection Agency (Karen Hamernik, Kenneth Haymes, Susan Hester and
Thomas McClintock).

Rezensionen

"For those wishing to gain an insight the potential power of toxicogenomics in toxicity assessment Toxicogenomics: A Powerful Tool for Toxicity Assessment will be if interest." (BTS Newsletter, Summer 2009)

Produkt-Details

• Erscheint lt. Verlag: 20.11.2008
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
• Themenwelt: Naturwissenschaften ► Chemie ► Anorganische Chemie
• Themenwelt: Naturwissenschaften ► Chemie ► Technische Chemie
• Themenwelt: Technik
• Schlagworte: Chemie • Chemistry • Drug Discovery & Development • genomics • Lebensmitteltechnik • Toxicology • Toxikologie • Wirkstoffforschung u. -entwicklung
• ISBN-10: 0-470-69964-7 / 0470699647
• ISBN-13: 978-0-470-69964-5 / 9780470699645