Brain Energetics and Neuronal Activity (eBook)

Applications to fMRI and Medicine

Robert Shulman, Douglas Rothman (Herausgeber)

eBook Download: PDF

2005 | 1. Auflage
336 Seiten
John Wiley & Sons (Verlag)
978-0-470-02051-7 (ISBN)

Infos

This book is unique in linking in vivo ¯13C NMR
measurements of neuronal activity and energetics with applications
to functional imaging and certain disease states It provides a
fundamental neurochemical explanation of brain activity applicable
to functional imaging, theories of neuronal activity and disease
states, e.g. epilepsy, psychiatric diseases and developmental
disorders.

* Novel and potentially controversial

* Will inspire future research directions

Autor

Robert Gerson Shulman is a biophysicist and Sterling Professor Emeritus of Molecular Biophysics and Biochemistry and a Senior Research Scientist at the Department Diagnostic Radiology at Yale University. Douglas L. Rothman is the editor of Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine, published by Wiley.

Inhalt

Contributors.

Foreword.

Section A: Background.

1. Introduction (Douglas L. Rothman and Robert G. Shulman).

2. Energy Metabolism in Neural Tissues in vivo at Rest and in
Functionally Altered States (Louis Sokoloff).

3. Techniques-MRS, fMRI, 13C NMR, Indirect Detection of
13C (Robin de Graaf).

4. Metabolic Modeling Analysis of Brain Metabolism (Graeme
Mason).

Section B: Neuroenergetics and Activity.

5. Cerebral Energetics and Neurotransmitter Fluxes (Nicola R.
Sibson).

6. NMR Studies of the Metabolism and Energetics of GABA
Neurotransmitter Pathways (Kevin L. Behar and Douglas L.
Rothman).

7. Neural Energy Consumption and the Representation of Mental
Events (Simon B. Laughlin and David Attwell).

8. Imaging Cerebral Metabolic Rate of Oxygen Consumption (CMRO2)
using 17O NMR Approach at Ultrahigh Field (Wei Chen, Xiao-Hong Zhu
and Kamil Ugurbil).

9. Deriving Changes in CMRO2 from Calibrated fMRI (Fahmeed
Hyder).

10. Relationship between CMRO2 and Neuronal Activity (Fahmeed
Hyder and Hal Blumenfeld).

Section C: Clinical Beginnings.

11. NMR Studies of Bioenergetic Impairment in Human Epilepsy
(Hoby P. Hetherington, Jullie W. Pan and Dennis D. Spencer).

12. MRS Studies of the Role of Altered Glutamate and GABA
Neurotransmitter Metabolism in the Pathophysiology of Epilepsy
(Ognen A. C. Petroff and Dennis D. Spencer).

13. The Role of Altered Energetics of Neurotransmitter Systems
in Psychiatric Disease (Graeme F. Mason).

Section D: Brain and Mind.

14. Long-term Memory: Do Incremental Signals Reflect Engagement
of Cognitive Processes? (Jed A. Meltzer and R. Todd Constable).

15. Using fMRI to Study the Mind and Brain (Bruce E.
Wexler).

16. Brain and Mind: an NMR Perspective (Robert G. Shulman and
Fahmeed Hyder).

17. The Role of the NMR Baseline Signal in the Study of
Consciousness: the Restless Brain (Robert G. Shulman).

Index.

Rezensionen

"...high quality scientific data and...consistent formatting...I would recommend this book as a reference for those in the academic field who work closely with MR physicists..." (AuntMinnie.com, May 24, 2006)

Produkt-Details

• Erscheint lt. Verlag: 19.8.2005
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Medizinische Fachgebiete ► Radiologie / Bildgebende Verfahren ► Kernspintomographie (MRT)
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Biowissenschaften • Cardiovascular Disease • Cell & Molecular Biology • Chemie • Chemistry • Gehirn • In vivo • Kardiovaskuläre Erkrankungen • Kardiovaskuläre Erkrankungen • Life Sciences • Medical Science • Medizin • NMR Spectroscopy / MRI / Imaging • NMR-Spektroskopie / MRT / Bildgebende Verfahren • NMR-Tomographie • Zell- u. Molekularbiologie
• ISBN-10: 0-470-02051-2 / 0470020512
• ISBN-13: 978-0-470-02051-7 / 9780470020517