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Physical Principles in Sensing and Signaling - Robert G. Endres

Physical Principles in Sensing and Signaling

With an Introduction to Modeling in Biology
Buch | Hardcover
158 Seiten
2013
Oxford University Press (Verlag)
978-0-19-960063-2 (ISBN)
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The book addresses how biological cells work, and specifically achieve their remarkable sensing and signaling properties using insights from physics and engineering. The book aims to teach concepts, omitting many of the technical details, and hence should attract a broad readership.
Although invisible to the bare eye, bacterial cells are large enough to make complex decisions. Cells are composed of thousands of different molecular species including DNA, proteins, and smaller molecules, allowing them to sense their environment, to process this information, and to respond accordingly. Such responses include expression of genes or the control of their movement. Despite these properties, a living cell exists in the physical world and follows its laws. Keeping this in mind can help answer questions such as how cells work and why they implement solutions to problems the way they do. Applying physical principles in biology allows researchers to solve challenging problems at the interface between biology and the physical sciences, including how accurately biological cells can sense chemicals in their environment, how cells encode physical stimuli in biochemical pathways, or how cells amplify signals and adapt to persistent stimulation. In this book, the reader is introduced to this fascinating topic without the need for extensive mathematical details or huge prior knowledge in biological physics.

At Imperial College Robert Endres heads the Biological Physics Group. Recently he won the prestigious ERC Strating Grant award. Before moving to the United Kingdom, Robert was a postdoc with Prof. Ned Wingreen in the Molecular Biology Department at Princeton University, where his main research accomplishments were the understanding of the remarkable signalling properties of bacterial chemotaxis and the atomistic prediction of protein-DNA binding sites.

1. Preface ; 2. Introduction ; 3. Physical concepts ; 4. Mathematical tools ; 5. Chemotaxis in bacterium Escherichia coli ; 6. Signal amplification and integration ; 7. Robust precise adaptation ; 8. Polar receptor localization and clustering ; 9. Accuracy of sensing ; 10. Motor impulse response ; 11. Optimization of pathway ; 12. 'Seeing' like a bacterium ; 13. Beyond E. coli chemotaxis

Erscheint lt. Verlag 10.1.2013
Zusatzinfo 69 b/w illustrations
Verlagsort Oxford
Sprache englisch
Maße 198 x 246 mm
Gewicht 524 g
Themenwelt Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Zellbiologie
Naturwissenschaften Physik / Astronomie Angewandte Physik
ISBN-10 0-19-960063-5 / 0199600635
ISBN-13 978-0-19-960063-2 / 9780199600632
Zustand Neuware
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