Modern Fluoroorganic Chemistry (eBook)

Synthesis, Reactivity, Applications

Peer Kirsch (Autor)

eBook Download: PDF

2006 | 1. Auflage
XII, 308 Seiten
Wiley-VCH (Verlag)
978-3-527-60419-7 (ISBN)

Infos

In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds, the main part of the book presents a wide range of synthetic methodologies and the experimental procedures selected undeniably show that this can be done with standard laboratory equipment. To round off, the author looks at fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers and more besides.
This long-awaited book represents an indispensable source of high quality information for everyone working in the field. Die Chemie von fluororganischen Verbindungen ist aufregend, ungewöhnlich, aber nicht mehr exotisch - und von jedem Labor mit Standardausrüstung zu bewältigen. Diesen seinen Standpunkt untermauert der Autor dieses Bandes mit zahlreichen gut nachvollziehbaren Synthesevorschriften und Versuchsanleitungen, ergänzt durch Informationen zu Anwendungen fluorhaltiger Substanzen in Flüssigkristallen oder Polymeren. Eine lange erwartete Publikation, unentbehrlich für einschlägig interessierte Synthesechemiker.

Autor

Peer Kirsch received his PhD under the supervision of Prof. Staab at the Max Planck Insitute for Medical Research in Heidelberg. He joined the Liquid Crystal Division of Merck KGaA in 1995 and his research interest is the application of fluorine chemistry for the design and synthesis of liquid crystals.

Inhalt

INTRODUCTION
Why Organofluorine Chemistry
History
The Basic Materials
The Unique Properties of Organofluorine Compounds
Application of Organofluorine Compounds
SYNTHESIS OF COMPLEX ORGANOFLUORINE COMPOUNDS
Analytics of Organofluorine Compounds
Introduction of Fluorine
Perfluoroalkylation
Special Fluorinated Groups
Syntheses with Fluorinated Building Blocks
FLUOROUS CHEMISTRY
Fluorous Biphasic Catalysis
Fluorous Synthesis and Combinatorial Chemistry
FLUOROPHARMACEUTICALS
Why Fluorinated Pharmaceuticals?
Lipophilicity
Hydrogen bonding and Electrostatic Interactions
Metabolic Stabilization
Bioisosteric Mimicking
Orthogonal Reactivity and Suicide Inhibition
LIQUID CRYSTALS FOR ACTIVE MATRIX LCDs
Calamatic Liquid Crystals: A Short Introduction
Functioning of an Active Matrix LCD
Why Fluorinated Liquid Crystals?
Fluorinated Polar Groups
Fluorinated Bridge Structures
REFERENCES
INTRODUCTION
Why Organofluorine Chemistry
History
The Basic Materials
The Unique Properties of Organofluorine Compounds
SYNTHESIS OF COMPLEX ORGANOFLUORINE COMPOUNDS
Introduction of Fluorine
Perfluoroalkylation
Special Fluorinated Groups
Syntheses with Fluorinated Building Blocks
FLUOROUS CHEMISTRY
Fluorous Biphasic Catalysis
Fluorous Synthesis and Combinatorial Chemistry
FLUOROPHARMACEUTICALS
Why Fluorinated Pharmaceuticals?
Lipophilicity
Hydrogen bonding and Electrostatic Interactions
Metabolic Stabilization
Bioisosteric Mimicking
Orthogonal Reactivity and Suicide Inhibition
LIQUID CRYSTALS FOR ACTIVE MATRIX LCDs
Calamatic Liquid Crystals: A Short Introduction
Functioning of an Active Matrix LCD
Why Fluorinated Liquid Crystals?
Fluorinated Polar Groups
Fluorinated Bridge Structures
REFERENCES

Rezensionen

"... a well-produced book with attractive graphics, photos and schemes. Throughout the book, coloured electrostatic maps of small organofluorine compounds are used to illustrate charge distributions. These are effective as well as attractive. I would point any organic chemist to this book who wants to learn about and do some fluorine chemistry. It provides uncluttered descriptions and a clear orientation to the literature in this important area of the organic chemistry."
CHEMBIOCHEM - A European Journal of Chemical Biology

"Von einem geschichtlichen Überblick bis hin zu neuesten Methoden und Anwendungen zeigt das Buch die gesamte Bandbreite an fluororganischer Chemie auf."

www.organische-chemie.ch

"... der Autor, ein renommierter Industriemechaniker, bewies bei der Auswahl der Themen ein feines Gespür für die wichtigsten Aspekte dieses noch in der Entwicklung befindlichen Forschungsgebiets. .... Das Layout ist ansprechend und die graphische Darstellung der Strukturformeln klar und einheitlich. Ein zweckmäßiges Sachwortvrzeichnis rundet den positiven Eindruck ab. .... Praktiker auf dem Gebiet werden das Buch bald als Referenzwerk zu schätzen wissen, aber auch fortgeschrittenen Studenten kann es als vorlesungsbegleitende Lektüre gute Dienste leisten.

G. K. Surya Prakash, Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, Angewandte Chemie, 2. Märzheft 2005-117/10 + International Edition 2005-44/10

Produkt-Details

• Erscheint lt. Verlag: 6.3.2006
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Schlagworte: Chemie • Chemistry • Fluorverbindungen • Katalyse • Methods - Synthesis & Techniques • Organic Chemistry • Organische Chemie • Organische Chemie / Methoden, Synthesen, Verfahren
• ISBN-10: 3-527-60419-7 / 3527604197
• ISBN-13: 978-3-527-60419-7 / 9783527604197