Articular Cartilage
Crc Press Inc (Verlag)
978-1-4398-5324-5 (ISBN)
- Titel erscheint in neuer Auflage
- Artikel merken
The authors examine the major events and signaling molecules that lead to development of articular cartilage from precursor cells, and the changes in cartilage as it matures and ages. They focus on the epidemiology, etiopathogenesis, and therapeutic approaches for cartilage injury and the major arthritides that affect cartilage and the synovial joints such as osteoarthritis, rheumatoid arthritis, and gout. They supply an up-to-date overview of the field of tissue engineering as applied to articular cartilage repair. They examine a number of methods used to assess structure, composition, biology, and biomechanical function. Each chapter contains extensive references to enhance additional study.
The book’s comprehensive focus on multiple aspects of articular cartilage sets it apart from other tissue engineering or developmental biology-based books available. It includes important discussions and perspectives on many of the remaining challenges and opportunities in the development and translation of new approaches for treating diseases of articular cartilage. It also provides detailed working protocols for many of the methods used to study articular cartilage, coverage of current treatment options, and business and regulatory aspects of the development of cartilage products. It provides a deeper understanding that will help with the development of new products and clinical applications.
Kyriacos A. Athanasiou is a Distinguished Professor and Chair Department of Biomedical Engineering at the University of California, Davis. Eric M. Darling is an Assistant Professor of Molecular Pharmacology, Physiology and Biotechnology at Brown University, Rhode Island. Jerry C. Hu is a Senior Research Scientist in the Department of Biomedical Engineering at the University of California, Davis.
Structure and Function of Cartilage
Introduction
Chondrocytes and Their Cellular Characteristics
Cartilage Matrix Characteristics and Organization
Articular Cartilage Biomechanical Properties
Chapter Concepts
References
Articular Cartilage Development
Introduction
Cellular Behavior during Embryogenesis
Articular Cartilage Growth and Maturation
Signaling Pathways during Development and Maintenance of Articular Cartilage
Signaling Factors
Chapter Concepts
References
Articular Cartilage Pathology and Therapies
Introduction
Cartilage Injuries
Current and Emerging Therapies for Articular Cartilage Repair and Arthritis
Motivation for Tissue Engineering
Chapter Concepts
Appendix
References
Tissue Engineering of Articular Cartilage
Introduction
The Need for In Vitro Tissue Engineering
Cell Source
Biomaterials and Scaffold Design
Bioactive Molecules for Cartilage Engineering
Bioreactors and Mechanical Stimulation
Convergence of Stimuli
Chapter Concepts
References
Methods for Evaluating Articular Cartilage Quality
Introduction
Imaging Techniques
Histology, Immunohistochemistry, and Other Ultrastructural Techniques
Techniques for the Quantitative Assessment of Biochemical Components
Biomechanical Techniques
Animal Models
Clinical Scoring Systems
Chapter Concepts
References
Perspectives on the Translational Aspects of Articular Cartilage Biology
Introduction
Challenges and Opportunities in Articular Cartilage Biology and Regeneration
Immune Response, Immunogenicity, and Transplants
Business Aspects and Regulatory Affairs
Statutes and Guidelines
Chapter Concepts
References
Experimental Protocols
Introduction
Tissue and Cell Culture
Gross Morphology, Histology, and Immunohistochemistry
Protein Analysis
Insoluble Matrix Component Extraction and Assaying
RNA Extraction and Gene Expression
Assaying Tissue Biomechanical Properties
Animal Protocols
| Zusatzinfo | 16 pages/32 figure insert follows page 164; 9 Tables, black and white; 32 Illustrations, color; 66 Illustrations, black and white |
|---|---|
| Verlagsort | Bosa Roca |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 771 g |
| Themenwelt | Medizinische Fachgebiete ► Chirurgie ► Unfallchirurgie / Orthopädie |
| Naturwissenschaften ► Biologie | |
| Technik ► Umwelttechnik / Biotechnologie | |
| ISBN-10 | 1-4398-5324-X / 143985324X |
| ISBN-13 | 978-1-4398-5324-5 / 9781439853245 |
| Zustand | Neuware |
| Haben Sie eine Frage zum Produkt? |
aus dem Bereich
