Programmed Cell Death in Animals and Plants
Bios Scientific Publishers Ltd (Verlag)
978-1-85996-167-4 (ISBN)
School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK. School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK. School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK.
Contributors -- Abbreviations -- Preface -- 1 Apoptotic cell death: from worms to wombats ... but what about the weeds? 1 /M.O. Hengartnerand J.A. Bryant -- Caenorhabditis elegans: the worm that turned ... into a model multicellular eukaryote -- The molecular mechanisms of programmed cell death in Caenorhabditis elegans -- Comparison with mammalian apoptosis -- Plants, from Arabidopsis to Zinnia -- General conclusions -- 2 Caspases - at the cutting edge of cell death /H.R. Stennicke -- Introduction -- Caspases and their properties -- Structure of the caspases -- Activation and regulation of the caspases -- Evolution of the caspases -- 3 Modulation of death receptor signalling /P. Schneider and J.Tschopp -- Introduction -- Death receptors and apoptosis -- Activation of death receptors by death ligands -- Decoy receptors -- Inhibition of death receptor by FLIP -- Conclusion -- 4 The role of the Bcl-2 family in the modulation of apoptosis /C. Pepper and P. Bentley -- Introduction -- Bcl-2 family: life or death promoters -- Function of the Bcl-2 family proteins -- Cellular control of Bcl-2 family proteins -- Over-expression of Bcl-2 family proteins and chemoresistance -- Drug resistance in B-CLL -- Strategies for inhibiting Bcl-2 function in B-CLL -- Conclusions -- 5 The role of granzymes and serpins in regulating cell growth and death /P. Coughlin, E. Morris and L. Hampson -- Introduction -- Induction of apoptosis by cytotoxic T cells and natural killer cells -- How does granzyme B gain access to the interior of target cells? -- Molecular targets of granzyme B -- Regulation of granzyme B activity -- The intracellular regulation of granzyme B by PI-9 -- The role of intracellular serpins in cell growth and death -- Conclusions -- 6 Mitochondria and cell death: a pore way to die? /A.P. Halestrap, J.P. Gillespie, A. O'Toole and E. Doran -- Introduction -- The mitochondrial permeability transition -- Mitochondria and apoptosis -- 7 Regulation of apoptosis by cell metabolism
| Erscheint lt. Verlag | 15.6.2000 |
|---|---|
| Reihe/Serie | Society for Experimental Biology |
| Verlagsort | London |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 453 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Botanik |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| ISBN-10 | 1-85996-167-3 / 1859961673 |
| ISBN-13 | 978-1-85996-167-4 / 9781859961674 |
| Zustand | Neuware |
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