The CD4 Molecule

Roles in T Lymphocytes and in HIV Disease

Buch | Softcover

XIII, 182 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1996
Springer Berlin (Verlag)
978-3-642-79800-9 (ISBN)

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During the late 1970's the application of hybridoma technology led to an explosion in the discovery and characterization of proteins expressed at the surface of hematopoietic cells. The understanding of T lymphocyte biology benefited enormously from this advance and from newly developed techniques for obtaining clonal T cells. Application of these methodologies resulted in the identification of the clonally restricted T cell antigen receptors (TCRs) and of a number of other molecules expressed more broadly on T cells. Among these, the CD4 and CD8 glycoproteins stood out because they were differentially expressed on distinct functional subsets of T lymphocytes. Moreover, blocking studies with monoclonal antibodies sug gested a functional role for CD4 and CD8 in T cell responses to antigen. Shortly thereafter, it was shown that T helper cells were the primary targets for the human immunodeficiency virus (HIV) and that CD4 serves as the viral receptor on these cells. These findings fueled an intense interest in CD4 during the last decade, in the hope that understanding the molecular nature of the HIV-CD4 interaction could hold the key to controlling AIDS.

List of Contents.- The Structure of CD4.- The Structural Basis of CD4-MHC Class II Interactions: Coreceptor Contributions to T Cell Receptor Antigen Recognition and Oligomerization-Dependent Signal Transduction.- CD4 and Signal Transduction.- Signal Transduction by the Lymphocyte-Specific Tyrosine Protein Kinase p56lck.- The Regulation and Function of the CD4 Coreceptor During T Lymphocyte Development.- Endocytic and Exocytic Regulation of CD4 Expression and Function.- The Receptor for HIV: Dissection of CD4 and Studies on Putative Accessory Factors.- The Role of CD4 in HIV Envelope-Mediated Pathogenesis.

"...will undoubtedly provide an outstanding reference for students and researchers for some years to come." - Immunology Today

Erscheint lt. Verlag	30.12.2011
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XIII, 182 p. 1 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	311 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	AIDS • Antigen • CD4 • Cell • HIV • HIV-Erkrankung • immune response • Immunodeficiency • Infection • pathogenesis • Protein • signal transduction • Signaltransduktionskette • T Cell • T Cells • Thymus • T-Zelle • Virus
ISBN-10	3-642-79800-4 / 3642798004
ISBN-13	978-3-642-79800-9 / 9783642798009
Zustand	Neuware