Recombinant DNA Technologies in Neuroendocrinology

Buch | Softcover

V, 222 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1993
Springer Berlin (Verlag)
978-3-642-77505-5 (ISBN)

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1.1 Mechanism of Action of Glucocorticoid Hormones The current model of glucocorticoid hormone action is summarized in Fig. 1. After synthesis, glucocorticoids are secreted into the blood stream and trans ported to target cells where they bind with high affinity (K-1O-9M) and d specificity to the intracellular glucocorticoid receptor (GR) protein. The sub cellular localization of hormone-free GR is still a controversial issue. However, most data support the idea that unliganded GR is in the cytoplasmic compartment or loosely associated with the nucleus (Picard and Yamamoto 1987; Gustafsson et al. 1987 and references therein; LaFond et al. 1988; Gasc et al. 1989). Upon ligand binding, GR is activated into a form capable of interacting with DNA. The mechanism of GR activation probably involves a conformational change and dis sociation from nonreceptor components, e.g., the 90-kDA heat shock protein (hsp90: Pratt et al. 1988; Bresnick et al. 1989; Denis and Gustafsson 1989). The subcellular location of activated GR has been firmly established to be inside the nucleus. In vivo, the hormone-receptor complex interacts with specific DNA Activation r:::.. ~ qc [!3-GC ... &.GC~ j ~ ? , BIOLOGICAL EFFECTS " t , Active Protein , , ~Vllent.

Axonal Messenger RNA Transport: Fact or Fiction?.- Molecular Mechanisms of Regulation of Gene Expression by Glucocorticoids.- Regulation of Neuropeptide Gene Expression.- Opioid Peptide Genes: Sructure and Regulation.- Regulation of Gene Expression of Pituitary Hormones by Hypophysiotropic Hormones.- Use of Transgenic Animals in the Study of Neuropeptide Genes.- Molecular Alterations in Nerve Cells: Direct Manipulation and Physiological Mediation.- Electrophysiological Methods for Studying Endocrine Cells and Neuronal Activity from the Hypothalamo-hypophyseal System.

Erscheint lt. Verlag	21.12.2011
Reihe/Serie	Current Topics in Neuroendocrinology
Co-Autor	Y. Dong, A. Fukamizu, R.H. Goodman, J.-A. Gustafsson, V. Höllt, M.G. Kaplitt, L.A. Kukstas, P.-M. Lledo, M.J. Low, K. Murakami, Y. Nakai, S. Okret, D.W. Pfaff, S.D. Rabkin, R. Rehfuss, D. Richter, T. Tsukada, J.-D. Vincent, K. Walton
Zusatzinfo	V, 222 p. 16 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	358 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	attention • endocrinology • Endokrinologie • gene expression • Genexpression • Neurobiologie • Neurobiology • Neuroendocrinology • Neuropeptide • Neuropeptides • peptide processing • Protein • Transgene Tiere • Transgenic animals
ISBN-10	3-642-77505-5 / 3642775055
ISBN-13	978-3-642-77505-5 / 9783642775055
Zustand	Neuware