Membrane Defenses Against Attack by Complement and Perforins

Buch | Softcover

VIII, 188 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1992
Springer Berlin (Verlag)
978-3-642-77016-6 (ISBN)

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In this volume a comprehensive review of membrane proteinsthat regulate complement and perforin-mediated cytolysis ispresented. A detailed analysisis provided of thebiochemical, molecular, and functional features of theseproteins; the glycosyl phosphatidylinositol linkedproteins are covered, with emphasis placed on the functionalimportance of this type of membrane anchor. Further chaptersinclude reviews of the effects of complement activation oncells that are metabolically active, and of the regulationof cell killing by cytotoxic lymphocytes, considering thesimilarities and disparities between the complement andperforin systems. The therapeutic use of recombinant CR1for immune-mediated pathophysiological processes isdiscussed in a separate section.

List of Contents.- Regulation of Complement by Membrane Proteins: An Overview.- Decay Accelerating Factor (CD55).- Complement Receptor Type 1.- Membrane Cofactor Protein.- Membrane Inhibitor of Reactive Lysis.- Homologous Restriction Factor.- The Effects of Complement Activation on Platelets.- Effects of the Membrane Attack Complex of Complement on Nucleated Cells.- Glycosyl-Phosphatidylinositol Anchoring of Membrane Proteins.- Paroxysmal Nocturnal Hemoglobinuria.- Perforin-Structure, Function, and Regulation.

Erscheint lt. Verlag	16.12.2011
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	VIII, 188 p. 5 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	317 g
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Activation • Anämie • anemia • Cell • cell membrane • Hämoglobulinurie • hämolytische • hemoglobinuria, paroxysmal nocturnal • hemolytic anemia • Komplementsystem • Lymphocytes • Membrane • nächtliche • paroxysmale • Protein • proteins • proteins, glycosyl phosphatydilinositol anchored • proteins, membrane • receptor • Regulation • Zellmembran
ISBN-10	3-642-77016-9 / 3642770169
ISBN-13	978-3-642-77016-6 / 9783642770166
Zustand	Neuware