Neuronal Growth Factors

Buch | Softcover

IX, 173 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1991
Springer Berlin (Verlag)
978-3-642-75749-5 (ISBN)

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A host of environmental factors regulate the embryonic development of neurons. In adults, the survival of neurons, the regeneration of damaged axons, and plastic changes in axonal arborization are also controlled by a complex array of environmental cues. An important category of regulatory influences involves target-derived hormone-like peptides act ing on neuronal cell surface receptors. Nerve growth factor (NGF) was the first such factor to be characterized (LEVI MONTALCINI and HAMBURGER 1953) and has served as the model against which all similar factors are compared. A number of factors with properties similar to NGF have been described with activities toward differing populations of neurons. Many of these factors have been characterized only poorly at the biochemical level. However, several factors have been charac terized to the extent that molecular clones are available and complete amino acid sequences are known. These include: three structurally related factors, NGF itself (SCOTT et al. 1983), brain-derived neurotrophic factor (BDNF) (LEIBROCK et al. 1989), and neurotrophin-3 (NT-3) (MAISONPIERRE et al. 1990; HOHN et al. 1990); ciliary neurotrophic factor (CNTF) (LIN et al. 1989) and a second set of structural homologs; acidic and basic fibroblast growth factors (aFGF, bFGF) (ABRAHAM et al. 1986; JAYE et al. 1986). Investigators have cloned the receptors for NGF (JOHNSON et al. 1986; RADEKE et al. 1987) and FGF (LEE et al. 1989).

The number of known neurotrophic peptide factors is rapidly expanding yet few are well characterized. Neuronal Growth Factors discusses in detail current understanding of biochemical and biological aspects of two of the best characterized factors.

Structure and Biosynthesis of Nerve Growth Factor.- Biochemical Characterization of the Nerve Growth Factor Receptor in Neural-Related Tumors.- The Membrane Receptor for Nerve Growth Factor.- Tissue Localization of Nerve Growth Factor and Nerve Growth Factor Receptors.- Nerve Growth Factor Function in the Central Nervous System.- The Fibroblast Growth Factors: An Emerging Family of Neural Growth Factors.- Dissecting the Mode of Action of a Neuronal Growth Factor.

Erscheint lt. Verlag	13.12.2011
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	IX, 173 p. 7 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	299 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Alzheimer • Alzheimer's disease • biochemistry • Biology • Cell • Cell Biology • Diseases • firbroblast growth factor • Nerve growth factor • nervous system • Neural development • Neurobiologie • Neurobiology • Neurochemie • neurochemistry • Regulation • signal transduction • Wachstum • Wachstumsfaktor • Wachstumsfaktoren • Zellbiologie
ISBN-10	3-642-75749-9 / 3642757499
ISBN-13	978-3-642-75749-5 / 9783642757495
Zustand	Neuware