Bacterial Capsules

Buch | Softcover

IX, 162 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1990
Springer Berlin (Verlag)
978-3-642-74696-3 (ISBN)

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Many bacteria, such as certain Neisseria and Haemophilus or Escherichia coli, are able to withstand the bactericidal activity of complement and phagocytes. This bacterial self protection is brought about by encapsulation. Bacterial capsules thus enable the pathogenic bacteria to survive in the host by counter action or evasion of the nonspecific host defense in the early pre immune phase of an infection. It is only in the late immune phase of the infection, when specific anticapsular antibodies are formed and enforce the host's defense system, that this protective action is overcome. Encapsulated bacteria are then killed and eliminated. Interestingly, some capsules can not or only inefficiently be handled by the immune system. The ensuing lack of antibody formation results in a prolonged susceptibility of the host to the pathogenic bacteria exhibiting such capsules. It was found that bacterial capsules consist of acidic poly saccharides. From this it followed that the role of the capsules in the interaction of encapsulated bacteria with the host may be due to the chemistry of the capsular polysaccharides. This led to intensive studies of capsular polysaccharides in many laboratories. Our increasing knowledge of the structural features of capsular polysaccharides prompted not only immuno chemical studies analyzing the interactions of these poly saccharide antigens and characterizing the epitopes, but also investigations into their biosynthesis. These studies were complemented and supported by genetic analyses. Today many interdisciplinary investigations of capsular polysaccharides are in progress.

Genetics of Capsular Polysaccharide Production in Bacteria.- Structure and Biosynthesis of the Capsular Antigens of Escherichia coli.- The Serology of Capsular Antigens.- The Role of Bacterial Polysaccharide Capsules as Virulence Factors.- The Biologic Significance of Bacterial Encapsulation.- Capsular Polysaccharides as Vaccine Candidates.- Visualization of the Bacterial Polysaccharide Capsule.

Erscheint lt. Verlag	16.12.2011
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	IX, 162 p. 16 illus.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 242 mm
Gewicht	312 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Antigene • Antigenes • biochemistry • Gene organisation • Genorganisation • Infection • Infektionen • Kapselpolysaccharide • Microbiology • Polysaccharid • Polysaccharide capsules
ISBN-10	3-642-74696-9 / 3642746969
ISBN-13	978-3-642-74696-3 / 9783642746963
Zustand	Neuware