Current Topics in Microbiology and Immunology

Volume 102

M. Cooper, P. H. Hofschneider, H. Koprowski, F. Melchers, R. Rott, H. G. Schweiger, P. K. Vogt, R. Zinkernagel (Autoren)

Buch | Softcover

IV, 154 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1983
Springer Berlin (Verlag)
978-3-642-68908-6 (ISBN)

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Binding of various ligands (hormones, neurotransmitters, immunological stimuli) to membrane receptors induces the following changes: 1. Receptor redistribution (clustering, "capping") 2. Conformational changes that can be detected by fluorescent probes 3. Alteration in membrane fluidity (spin label and fluorescence polarization probes) 4. Changes in fluxes of ions and metabolites 5. Increased phospholipid turnover (especially of phosphatidyl inositol) 6. Activation of membrane-bound enzymes (adenyl cyclase, ATPase, transmethylases). Some of the early changes resulting from or associated with the binding (adsorption) of virions to the host cell membrane are of the same type. Adsorption of animal viruses to cells is the ftrst step in a chain of events resulting in the production of progeny virus on the one hand and in damage to cells and tissues on the other. In the classical studies of viral infection, cells are adsorbed with virus, usually for 60 min, and the changes induced by the virus in the host cell are recorded thereafter. In the past decade, more and more studies have been aimed at the events occurring in these ftrst 60 min of the so-called adsorption period. These studies deal with the nature of adsorption, e. g. , the ligand-receptor type of interaction between the virus and the cell membrane. Many receptors for viruses were identifted and so were the viral proteins which take part in adsorption.

Biosynthesis of the Collagen-Like C1q Molecule and Its Receptor Functions for Fc and Polyanionic Molecules of Macrophages.- Changes Induced in Cell Membranes Adsorbing Animal Viruses, Baeteriophages, and Colicins.- Fatty Acid Binding: A New Kind of Posttranslational Modification of Membrane Proteins.- Escherichia Coli Virus T1: Genetic Controls During Virus Infection.

Erscheint lt. Verlag	7.12.2011
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	IV, 154 p.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	288 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	ATPase • Cell • immunology • Infection • Microbiology • Protein • proteins • Virus
ISBN-10	3-642-68908-6 / 3642689086
ISBN-13	978-3-642-68908-6 / 9783642689086
Zustand	Neuware