Current Topics in Microbiology and Immunology

W. Henle, P. H. Hofschneider, P. Koldovský, H. Koprowski, O. Maaløe, F. Melchers, R. Rott, H. G. Schweiger, L. Syru?ek, P. K. Vogt (Autoren)

Buch | Softcover

IV, 278 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1981
Springer Berlin (Verlag)
978-3-642-68060-1 (ISBN)

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Several discoveries are noteworthy for allowing us to probe the recesses of the virus infected cell and to search for cryptic viral genomes which might provide clues in our studies of cancer etiology or developmental biology. One of the most notable was the dis covery of reverse transcriptase. This marked a momentous occasion in the history of molecular biology. Not only did it provide insight into the mechanism of persistence of retroviruses but it also provided us with an enzyme that could synthesize a DNA copy of any RNA. This DNA copy could then be used as a hybridization reagent to search for both complementary DNA and viral-specific RNA. Thus one could follow the course of any viral infection or probe in tumor cells for hidden viral genomes. Second, a great deal of credit must be given to the geneticists who isolated the various deletion mutants in the 'avian retrovirus system and thus provided us with the frrst means of isolating gene-spe cific probes. Finally, the laboratories which have mapped the genome have provided us with the framework in which to ask very specific questions with our gene-specific probes. Recently, numerous excellent reviews concerning various aspects of the retroviruses have appeared. In this review I shall not even attempt to present a comprehensive review of retroviruses.

Genetics of Reovirus.- The Transforming Protein of Avian Sarcoma Viruses and Its Homologue in Normal Cells.- Gene-Specific Probes for Avian Retroviruses.- Replication of Herpesvirus DNA.- The Obese Strain (OS) of Chickens With Spontaneous Autoimmune Thyroiditis: Review of Recent Data.- Nucleic Acid Independent Synthesis of Peptides.- The T-Cell Receptor Problem.- Retroviral Gene Expression.

Erscheint lt. Verlag	16.12.2011
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	IV, 278 p.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	501 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
Schlagworte	Cell • DNA • immunology • Infection • Microbiology • Molecular Biology • retroviruses • RNA • Tumor • Virus
ISBN-10	3-642-68060-7 / 3642680607
ISBN-13	978-3-642-68060-1 / 9783642680601
Zustand	Neuware