Current Topics in Microbiology and Immunology

W. Arber, S. Falkow, W. Henle, P. H. Hofschneider, J. H. Humphrey, J. Klein, P. Koldovský, H. Koprowski, O. Maaløe, F. Melchers, R. Rott, H. G. Schweiger, L. Syru?ek, P. K. Vogt (Autoren)

Buch | Softcover

IV, 184 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 1979
Springer Berlin (Verlag)
978-3-642-67324-5 (ISBN)

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The study of the genetic regulation of immune response to natural multidetermi nant immunogens was undertaken by the method of bidirectional selective breed ing of High or Low antibody responder lines of mice. Five Selections are described: Selection I, carried out for agglutinin responsiveness to sheep erythrocytes and pigeon erythrocytes alternated in each generation. Selection II, carried out for agglutinin responsiveness to sheep erythrocytes repeated in each generation. Selection III and Selection IV performed respectively for agglutinin response to flagellar or somatic antigens of Salmonella typhimurium and Salmonella oranienburg alternated in each generation. Selection V, performed for passive agglutinin response to bovine serum albumin and rabbit gamma globulin alternated in each generation. In each Selection the character investigated is polygenic. High and Low responder lines diverge progressively during the selective breeding. The maximal interline separation (selection limit) is reached in the 7th-16th generations. High and Low responder lines at selection limit are considered homozygous for the character submitted to se~ection. Their variance is therefore only due to environ mental effects. The difference in agglutinin titre between High and Low lines is 220-fold in Selection I, 103-fold in Selection II, 90-fold in Selection III, 85-fold in Selection IV and 275-fold in Selection V. The partition of genetic and environmental variances in the foundation popu lations of the five Selections is established. The proportion of genetic variance is 60% in Selection I; 49% in Selection II; 51% in Selection III; 47% in Selection IV and 76% in Selection V.

Fuchs, S. : Immunology of the Nicotinic Acetylcholine Receptor.- Biozzi, G. et al.: Genetics of Immuneresponsiveness to Natural Antigens in the Mouse.- Mayer, H., Schmidt, G.: Chemistry and Biology of the Enterobacterial Common Antigen.- Cumulative Author and Subject Index Volumes 40-85.

Erscheint lt. Verlag	15.11.2011
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	IV, 184 p.
Verlagsort	Berlin
Sprache	englisch
Maße	170 x 244 mm
Gewicht	341 g
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
Themenwelt	Naturwissenschaften ► Biologie
Schlagworte	Antigen • Biology • Environment • immune response • immunology • Microbiology
ISBN-10	3-642-67324-4 / 3642673244
ISBN-13	978-3-642-67324-5 / 9783642673245
Zustand	Neuware