Neuroendocrine Perspectives

Eugenio E. Müller, Robert M. MacLeod (Autoren)

Buch | Softcover

182 Seiten

2011 | Softcover reprint of the original 1st ed. 1990
Springer-Verlag New York Inc.
978-1-4612-8014-9 (ISBN)

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The flow of information in neuroendocrinology and related disciplines is vigorous, favored by the availability of sensitive and specific biochemical and histochemical techniques that advance our knowledge of CNS neurotransmitter and neuropeptide systems. Volume 8 of Neuroendocrine Perspectives illuminates new findings inthis areawhich add complexity to the traditional view ofthe hypothalamo- pituitary control, and to established concepts ofthe modulation ofbrain function by target hormones. In the first chapter, Ben-Jonathan exhaustively reviews evidence derived from her own work that demonstrates the importance of the posterior lobe as a regulator of prolactin secretion via two opposing influences, i. e. , dopamine released by the tuberohypophyseal dopaminergic system into the short portal vessels and a prolactin-releasing factor which is produced locally, though the identity of its innervating neurons is still unclear. Despite the wealth of information on prolactin and its cell of origin, little is known about the manner in which the hormone exerts its effects on target cells.
Frawley and coworkers thoroughlyexamine the direct actions ofprolactin on a broad spectrum ofmammalian tissues, dealing extensivelywith prolactin receptors and the putative second messengers. They also review new evidence, based on their original findings, for an indirect action ofprolactin exerted through the livervia synlactin and liver lactogenic factor, two extracellular modulators ofthe biological functions ofthe hormone. The relationships among the CNS, neuroendocrine and immune systems are bidirectional and constitute an integrated loop.

Prolactin Releasing and Inhibiting Factors in the Posterior Pituitaiy.- The Hypothalamo-Pituitary Axis.- Posterior Pituitary Dopamine.- Posterior Pituitary PRF.- Summary.- Effects of Prolactin on Target Cells.- Target and Actions of Prolactin.- The Signal Transduction Pathway of Prolactin’s Actions.- Indirect Effects of Prolactin on Target Tissues.- Conclusion.- Cellular and Molecular Aspects of the Neuroendocrine-Immune Dialogue in T-Cell Differentiation.- Cell Populations of the Thymic Microenvironment.- Pathways of T-Cell Differentiation.- Neural Crest Contribution to Thymic Development.- Neuroendocrine Markers of the Thymus.- Intrathymic Synthesis of Neuropeptides.- Thymic Neuropeptide Receptors.- Physiological Significance of Intrathymic Neuropeptide Synthesis.- Relationships between the Thymus and Endocrine Glands.- Summary.- The Hippocampus: A Site for Modulatory Interactions between Steroid Hormones, Neurotransmitters and Neuropeptides.- Adrenal Steroid Receptors in Brain.- Regulated Access of Steroids to Receptors In Vivo.- Neural Sites and Mechanism of Regulation of Pituitary-Adrenal Activity.- What Is the Impact of Glucocorticoids Secreted During Stress on the Hippocampus and Other Brain Regions?.- Neuropeptide Actions on and in the Hippocampus.- Glucocorticoids as General Maintenance Factors for Brain Structure and Glial Cell Neurochemistry.- Glucocorticoids and Neuronal Survival.- Conclusions and Speculations: Normal versus Pathological Effects of Glucocorticoids on the Hippocampus and Other Brain Structures.- Gastrointestinal Peptide Binding and Function in the Brain: Emphasis on Peptide YY.- Structure of the PP Family Peptide.- Distribution of PYY in the Gut and Brain.- PYY Receptors in the Brain.- PYY Actions in the Brain.- Summary.

Reihe/Serie	Neuroendocrine Perspectives ; 8
Zusatzinfo	XIV, 182 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Hypophyse • Neuroendokrinologie • Neuropeptide • Neuropeptides • pituitary
ISBN-10	1-4612-8014-1 / 1461280141
ISBN-13	978-1-4612-8014-9 / 9781461280149
Zustand	Neuware