Intracellular Protein Catabolism
Springer-Verlag New York Inc.
978-1-4613-8003-0 (ISBN)
The Tenth International Conference on Intracellular Protein Catabolism was held in Tokyo Japan, October 30-November 3, 1994. under the auspices of the International Committee on Proteolysis (lCOP). ICOP meetings have been held biennially in the USA, Europe, and Japan in turn. The previous three ICOP meetings (7th to 9th) were held in Shimoda, Japan, in 1988. in WildbadKreuth, Germany, in 1990, and in Williamsburg. Virginia, in 1992. Previous meetings were held in resort areas, this was the first meeting held in a large city. Attendance has grown every year so that nearly 400 participants from 19 different countries attended the Tokyo meeting. At the meeting, novel and updated results on the structure-function. physiology, biology, and pathology of proteases and inhibitors were discussed, together with cellular aspects of proteolysis and protein turnover. Thirty-nine invited papers and eight selected posters were presented orally and 171 poster presentations were discussed. This book documents almost all of the lectures and some selected posters. Since the world of proteolysis and protein turnover is expanding very rapidly. far beyond our expectations, it is impossible to cover all the new aspects of this field. However, this book will give an idea of the current status, trends. and directions of the field, and information necessary to understand what is and will be important in this field. Further. the editors hope that the novel ideas, approaches. methodologies, and important findings described in this book will stimulate further study on proteolysis and protein turnover.
1. The Metzincin-Superfamily of Zinc-Peptidases.- 2. Structure and Biosynthesis of Meprins.- 3. Involvement of Tissue Inhibitors of Metalloproteinases (TIMPS) during Matrix Metalloproteinase Activation.- 4. Structure and Function of a Novel Arginine-Specific Cysteine Proteinase (Argingipain) as a Major Periodontal Pathogenic Factor from Porphyromonas gingivalis.- 5. Discovery of a New Type of Proteinase Inhibitor Family Whose Members Have an Anchoring Sequence.- 6. Proposed Role of a ?-Interferon Inducible Proteasome-Regulator in Antigen Presentation.- 7. Novel Members of Mammalian Kexin Family Proteases, Pace 4C, Pace 4D, PC 7A and PC 7B.- 8. Phytocystatins and Their Target Enzymes-Molecular Cloning, Expression and Possible Functions.- 9. Horseshoe Crab Factor G: A New Heterodimeric Serine Protease Zymogen Sensitive to (l?3) ?-D-Glucan.- 10. The 43 kDa Papain-Inhibiting Protein in Psoriatic Epidermis Is Identical to Squamous Cell Carcinoma Antigen (SCC-Antigen).- 11. Alpha-Mercaptoacrylic Acid Derivatives as Novel Selective Calpain Inhibitors.- 12. Structural Aspects of Autophagy.- 13. Mechanism of Autophagy in Permeabilized Hepatocytes: Evidence for Regulation by GTP Binding Proteins.- 14. Lysosomal Proteinosis Based on Decreased Degradation of a Specific Protein, Mitochondrial ATP Synthase Subunit C: Batten Disease.- 15. The Neuronal Ceroid Lipofuscinoses (Batten Disease): A Group of Lysosomal Proteinoses.- 16. Energy-Dependent Degradation of a Mutant Serine:Pyruvate/Alanin: Glyoxylate Aminotransferase in a Primary Hyperoxaluria Type 1 Case.- 17. Endopeptidase-24.11 (Neprilysin) and Relatives: Twenty Years On.- 18. Function of Calpains: Possible Involvement in Myoblast Fusion.- 19. Cleavage of the Human C5A Receptor by Proteinases Derived from Porphyromonasgingivalis: Cleavage of Leukocyte C5a Receptor.- 20. Regulation of Programmed Cell Death by Interleukin-l?-Coverting Enzyme Family of Proteases.- 21. Inhibition of Cysteine and Serine Proteinases by the Cowpox Virus Serpin CRMA.- 22. Participation of Cathepsins B, H, and L in Perikaryal Condensation of CA1 Pyramidal Neurons Undergoing Apoptosis after Brief Ischemia.- 23. Protein and Gene Structures of 20S and 26S Proteasomes.- 24. The Proteasome and Protein Degradation in Yeast.- 25. Ubiquitin C-Terminal Hydrolases in Chick Skeletal Muscle.- 26. Protein Synthesis Elongation Factor EF-l? Is an Isopeptidase Essential for Ubiquitin-Dependent Degradation of Certain Proteolytic Substrates.- 27. Mechanisms and Regulation of Ubiquitin-Mediated Cyclin Degradation.- 28. Physiological Functions of Proteasomes in Ascidian Fertilization and Embryonic Cell Cycle.- 29. Cellular Proteases Involved in the Pathogenicity of Human Immunodeficiency and Influenza Viruses.- 30. HIV Protease Mutations Leading to Reduced Inhibitor Susceptibility.- 31. Aspartic Proteinases from Parasites.- 32. Tetanus and Botulism Neurotoxins: A Novel Group of Zinc-Endopeptidases.- 33. Endosome-Lysosomes, Ubiquitin and Neurodegeneration.- 34. Abnormalities of the Endosomal-Lysosomal System in Alzheimer’s Disease: Relationship to Disease Pathogenesis.- 35. Cathepsin B Expression in Human Tumors.- 36. TIMP-2 Mediates Cell Surface Binding of MMP-2.
| Reihe/Serie | Advances in Experimental Medicine and Biology ; 389 |
|---|---|
| Zusatzinfo | 320 p. |
| Verlagsort | New York, NY |
| Sprache | englisch |
| Maße | 170 x 244 mm |
| Themenwelt | Medizin / Pharmazie ► Gesundheitswesen |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Biologie ► Botanik | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| ISBN-10 | 1-4613-8003-0 / 1461380030 |
| ISBN-13 | 978-1-4613-8003-0 / 9781461380030 |
| Zustand | Neuware |
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