Signal Transduction and the Coordination of B Lymphocyte Development and Function II

Translation of BCR Signals to Specific Physiologic Outcomes

Louis B. Justement, Katherine A. Siminovitch (Herausgeber)

Buch | Softcover

XV, 172 Seiten

2011 | 1. Softcover reprint of the original 1st ed. 2000
Springer Berlin (Verlag)
978-3-642-64064-3 (ISBN)

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This volume provides a review of current research in the field of B cell development and differentiation with particular emphasis on signal transduction processes. The volume is divided into two parts that focus, respectively, on the basic biochemical pathways which regulate B cell biology and the role of signal transduction processes in regulating various aspects of B cell function, development and differentiation. In this second part the molecular processes involved in translating BCR engagement to specific biological outcomes are reviewed. Topics covered in this part include signal transduction via the pre-B cell antigen receptor complex, the control of immunoglobulin gene recombination and allelic exclusion, and molecular regulation of positive and negative selection. These latter chapters present information regarding processes which are critical for the B cell response to foreign antigen that leads to differentiation into antibody secreting plasma.

List of Contents.- B-Cell Antigen Receptor Signaling in Immature-Stage B Cells: Integrating Intrinsic and Extrinsic Signals.- Signaling Pathways that Control V(D)J Recombination.- B-Cell-Receptor-Dependent Positive and Negative Selection in Immature B Cells.- CD40-CD154 Interactions in B-Cell Signaling.- B-Lymphocyte Signaling Receptors and the Control of Class-II Antigen Processing.- Molecular Processes that Regulate Class Switching.

Erscheint lt. Verlag	18.9.2011
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XV, 172 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	305 g
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	B lymphocyte • lymphcyte • Lymphozyt • receptor ligand interactions • Signal • signal transduction
ISBN-10	3-642-64064-8 / 3642640648
ISBN-13	978-3-642-64064-3 / 9783642640643
Zustand	Neuware