The Endothelins

Winifred G. Nayler (Autor)

Buch | Softcover

XIII, 183 Seiten

2012 | 1. Softcover reprint of the original 1st ed. 1990
Springer Berlin (Verlag)
978-3-642-75874-4 (ISBN)

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"What we call the beginning is often the end, and to make an end is to make a beginning. The end is where we start from." T. S. ELIOT, "Geroniton" The discovery of endothelin-l was both an end and a beginning. It is an end because this discovery has started a plethora of investigations as to endothe1in's sites of production, mode of action, it's normal and abnormal physiological role and its involvement in a variety of pathological conditions ranging from renal failure to myocardial infarction, cardiac hypertrophy, hyperten sion, cyclosporine induced toxicity, mental depression, renal failure, stress related illness, and even stroke and sudden death. It is a beginning because no one can foresee where the investigations will ultimately lead, or how they will end. The discovery of the endothelins was a very recent event and soon specialist books will start to appear dealing in detail with different aspects of their chemistry, physiological role and pathological importance. The present book is intended to act as a guide and primer for those who are becoming intrigued by the many endothelin related articles which are now appearing in the journals but who as yet have not had the time or opportunity to be caught up in the web of enthusiasm and excitement which is motivating those more directly involved in the field of research.

1 The Discovery and General Properties of the Endothelins.- 2 The Chemistry of the Endothelins.- 3 The Biosynthesis of the Endothelins.- 4 Other Chemically-Related Toxins.- 5 The Contractile Effect of Endothelin-1.- 6 The Biochemical Events Involved in the Contractile and Positive Inotropic Activity of Endothelin-1.- 7 Endothelin Receptors: Their Distribution and Properties.- 8 Metabolism and Clearance of the Endothelins.- 9 Plasma, Tissue and Urine Endothelin-1.- 10 Effect of Various Pathological Conditions on Plasma Endothelin.- 11 Endothelin and the Kidney.- 12 Endothelin and the Brain.- 13 Endothelin and the Coronary Circulation.- 14 Endothelin-1 and the Heart.- 15 Endothelin, Cell Proliferation and Atherosclerosis.- 16 The Constrictor Effect of the Endothelins on Bronchiolar and Tracheal Smooth Muscle.- 17 Endothelin and Hypertension.- 18 The Endothelins and Platelet Aggregation.- 19 Do the Endothelins have a Future?.- References.

Erscheint lt. Verlag	10.1.2012
Zusatzinfo	XIII, 183 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	311 g
Themenwelt	Medizinische Fachgebiete ► Innere Medizin ► Kardiologie / Angiologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Biochemie
Schlagworte	Artery • Asthma • atherosclerosis • Atherosklerose • Bluthochdruck • Bluthochdruck / Hypertonie • Calcium • Chemistry • Circulation • Endothelium • heart • Heart disease • Hypertension • Ischaemic Heart Disease • Ischämie • kidney • Metabolism • Nierenversagen • platelet • receptor • Renal failure • synthesis • tissue
ISBN-10	3-642-75874-6 / 3642758746
ISBN-13	978-3-642-75874-4 / 9783642758744
Zustand	Neuware