Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Transduction of BCR Signals from the Cell Membrane to the Nucleus

Louis B. Justement, Katherine A. Siminovitch (Herausgeber)

Buch | Hardcover

XV, 267 Seiten

1999 | 2000
Springer Berlin (Verlag)
978-3-540-66002-6 (ISBN)

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Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.

Signal Transduction via the B-cell Antigen Receptor: The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases.- The B-Cell Antigen Receptor: Formation of Signaling Complexes and the Function of Adaptor Proteins.- Intermediary Signaling Effectors Coupling the B-Cell Receptor to the Nucleus.- Involvement of the Lymphocyte Cytoskeleton in Antigen-Receptor Signaling.- Pax-5/BSAP: Regulator of Specific Gene Expression and Differentiation in B Lymphocytes.- Receptor Modulators of B-Cell Receptor Signalling - CD19/CD22.- Positive and Negative Signaling in B Lymphocytes.

Erscheint lt. Verlag	19.8.1999
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XV, 267 p.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	540 g
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Themenwelt	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Activation • Antigen • B lymphocyte • Cell • Cell Biology • cell membrane • Cytoskeleton • Gene • gene expression • Lymphocytes • Lymphozyt • Lymphozyten • Membran (Biologie) • Membrane • Protein • proteins • receptor-ligand interactions • Regulation • Signal • signal transduction • transcription • Zelle (biolog.) • Zelle (Biologie)
ISBN-10	3-540-66002-X / 354066002X
ISBN-13	978-3-540-66002-6 / 9783540660026
Zustand	Neuware