Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis (eBook)

György Berencsi III (Herausgeber)

eBook Download: PDF

2012 | 2012
VIII, 464 Seiten
Springer Netherland (Verlag)
978-94-007-4216-1 (ISBN)

Infos

The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes. The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy. The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

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The maternal-fetal barrier represented by the syncytiotrophoblast was shown to be formed by epigenetically regulated endogeneous retroviruses. This barrier, however, possesses certain plasticity, it can be penetrated by nanoparticles of different size-classes, by methabolites, toxic substances by unidirectional or bidirectional transport enzyme systems, intercellular transport mechanisms and by maternal antibodies, immunocomplexes including virus-antibody complexes by specific receptor cascades. Bidirectional microchimerism perfuse the fetal organism with maternal cells and the maternal organism with fetal stem cells. Chromosomally integrated viruses (human herpesvirus 6, parvoviruses) latently infected lymphotropic herpesviruses and tumour cells can be present among the microchimeric cells which can survive in the recipient organisms in gradually decreasing number for several decades. Idiotypic interactions of T-B cells enable a generalization of single antigenic experiences and allow a transgenerational learning of the nascent immune system. The latter function is driven by maternal antibodies which represent a great deal of the mother's immunological knowledge of the external world of antigens. Therefore, maternal antibodies function as transgenerational messengers.

Inhalt

PrefaceBarriers of the human organism and their Achilles’ heels; Berencsi, György III and Takács, Mária  Recent results on the development of fetal immune system: Self, epigenetic regulation, fetal immune responses; Ay, Eva, Buzas, Krisztina, Banati, Ferenc and Minarovits, JanosThe role of endogenous retroviruses in the formation of syncytiotrophoblast and materno-fetal barrier; Ay, Eva, Banati, Ferenc, Turi-Balog, Katalin and Minarovits, JanosMaternal-fetal infections with human viruses; Berencsi, György III and Csire, MártaThe mechanism and significance of integration and vertical transmission of human herpesvirus 6 genome; Arbuckle, Jesse H., Pantry, Shara and Medveczky, Peter G.Maternal-fetal transmission of HBV; Bhat, Purnima Function of maternal idiotypic and anti-idiotypic antibodies as transgenerational messengers; Lemke, Hilmar, Tanasa, Radu I., Trad, Ahmad and Lange, HansPolarised transfer of proteins through the syncytiotrophobalst and tissue culture cell lines; Berencsi György III and Ördög KatalinFetal and neonatal illnesses caused or influenced by maternal transplacental IgG and/or therapeutic antibodies applied during pregnancy; Berencsi, György III and Szomor, KatalinMaternal-fetal microchimerism and fetal-juvenile malignancies; Berencsi, György III and Barcsay, ErzsebetMaternal tumours associated with and influenced by pregnancy; Berencsi, György IIISubject Index

Produkt-Details

• Erscheint lt. Verlag: 5.4.2012
• Zusatzinfo: VIII, 464 p.
• Verlagsort: Dordrecht
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pädiatrie
• Themenwelt: Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie
• Themenwelt: Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Bi-directional Microchimerism • Maternal-fetal Transcitosis • Pregnancy and Tumours • Transgenerational Messenger Antibodies • Vertical Transmission of HHV-6
• ISBN-10: 94-007-4216-9 / 9400742169
• ISBN-13: 978-94-007-4216-1 / 9789400742161