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Coarse-Grained Modelling of DNA and DNA Self-Assembly

Buch | Hardcover
XII, 176 Seiten
2012 | 2012
Springer Berlin (Verlag)
978-3-642-30516-0 (ISBN)
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This book presents and demonstrates a coarse-grained model of DNA, simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - it represents the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.

A Novel DNA Model.- Methods.- Finite Size Effects.- Stuctural and Mechanical Properties of Model DNA.- Thermodynamic Properties of Model DNA.- Modelling DNA Tweezers.- Modelling a DNA Walker.

Erscheint lt. Verlag 7.7.2012
Reihe/Serie Springer Theses
Zusatzinfo XII, 176 p.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 410 g
Themenwelt Naturwissenschaften Physik / Astronomie Angewandte Physik
Schlagworte Biological Motors • Coarse Grained Molecular Simulation • DNA nanotechnology • DNA Tweezers • DNA Walker • DNS (Desoxyribonukleinsäure) • molecular self-assembly • Monte Carlo Algorithms
ISBN-10 3-642-30516-4 / 3642305164
ISBN-13 978-3-642-30516-0 / 9783642305160
Zustand Neuware
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