Coarse-Grained Modelling of DNA and DNA Self-Assembly
Seiten
2012
|
2012
Springer Berlin (Verlag)
978-3-642-30516-0 (ISBN)
Springer Berlin (Verlag)
978-3-642-30516-0 (ISBN)
This book presents and demonstrates a coarse-grained model of DNA, simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - it represents the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
A Novel DNA Model.- Methods.- Finite Size Effects.- Stuctural and Mechanical Properties of Model DNA.- Thermodynamic Properties of Model DNA.- Modelling DNA Tweezers.- Modelling a DNA Walker.
| Erscheint lt. Verlag | 7.7.2012 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | XII, 176 p. |
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 410 g |
| Themenwelt | Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik |
| Schlagworte | Biological Motors • Coarse Grained Molecular Simulation • DNA nanotechnology • DNA Tweezers • DNA Walker • DNS (Desoxyribonukleinsäure) • molecular self-assembly • Monte Carlo Algorithms |
| ISBN-10 | 3-642-30516-4 / 3642305164 |
| ISBN-13 | 978-3-642-30516-0 / 9783642305160 |
| Zustand | Neuware |
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