Lectins (eBook)

Nathan Sharon, H. Lis (Autoren)

eBook Download: PDF

2007 | 2nd ed. 2007
XVIII, 454 Seiten
Springer Netherland (Verlag)
978-1-4020-6953-6 (ISBN)

Infos

This Second Edition brings readers up to date with all the latest findings in lectin research. Throughout this new edition, more than 200 figures and some thirty tables help readers visualize and understand key concepts and processes. The book starts with an overview of lectin research followed by a survey of the occurrence of lectins in nature. Other areas covered include the nutritional effects of lectins and their functions in nature.

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This is the second edition of our little red book Lectins published in 1989. In the intervening years well over 10,000 articles have appeared with lectins as the main subject, and more than twice as many in which they were touched upon, as well as around 20 books. In particular, great strides have been made in several areas of lectin research, about which little was known until the late 1980s. One prominent example is animal lectins, many of which have been discovered only during the last decade and the functions of several of which have been clarified, especially as to their key role in innate immunity. Another is the structure of lectins and of their combining sites. Thus, whereas at that time the three-dimensional structures of just three lectins and a few of their complexes with sugars had been elucidated, their numbers have increased to about 160 and over 200, respectively, and continue to grow unabated. Updating the information on these and other topics resulted in a marked expansion of the book, which is now nearly four times as long as the first edition, with 226 figures and 39 tables. Still, a few topics, such as carbohydrate-binding cytokines or bacterial toxins that are sometimes considered as lectins, have been dealt with only in passing. Similarly to the first edition, Lectins II starts with an overview of the history of lectin research.

Inhalt

Preface. 1. Introduction. 2. History: The Early Pioneers; Blood Group Specificity; Mitogenic Stimulation; A Tool For Cancer Research; Lectins Galore; From Primary To Three-Dimensional Structures; Tools For Biological And Medical Research; Insight Into Biological Functions; Into Contemporary Lectin Research. 3. Detection, Occurrence And Isolation: Detection; Occurrence; Isolation And Purification. 4. Specificity And Affinity: Methodology; Carbohydrate Specificity; Role Of Oligosaccharide Conformation; Effect Of Multivalency; Energetics Of Protein-Carbohydrate Interactions; Non-Carbohydrate Ligands; Leczymes. 5. Molecular Structure: Plant Lectins; Animal Lectins; Protozoan Lectins; Bacterial Lectins; Viral Hemagglutinins. 6. Combining Sites: Lectin-Carbohydrate Bonds; Plant Lectins; Animal Lectins; Bacterial Lectins; Viral Hemagglutinins. 7. Genetics, Molecular Biology And Evolution: Genetics And Molecular Biology; Evolution Of Carbohydrate Binding Activity. 8. Applications: Methodology; Glycoconjugates In Solution; Cell-Bound Carbohydrates; Mapping Neuronal Pathways; Cell Separation; Mitogenic Stimulation; Anti-Adhesion Therapy; Clinical Uses; Diagnosis And Targeting; Other Applications. 9. Lectin Cytotoxicity And Lectin-Resistant Cells: Mechanism Of Action; Lectin-Resistant Mutants. 10. Nutritional Effects: Lectins In Edible Plants; Deleterious Effects In The Intestinal Tract; Systemic Effects. 11. Functions: Theoretical Considerations; Plant Lectins; Animal Lectins; Microbial Lectins. Abbreviations. Appendix 1: Monosaccharides Recognized By Lectins. Appendix 2: Disaccharides And Oligosacharides. References. Index.

Produkt-Details

• Erscheint lt. Verlag: 3.11.2007
• Zusatzinfo: XVIII, 454 p.
• Verlagsort: Dordrecht
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Technik
• ISBN-10: 1-4020-6953-7 / 1402069537
• ISBN-13: 978-1-4020-6953-6 / 9781402069536