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Endocrine Disruptors and Puberty (eBook)

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2011 | 2012
XVIII, 378 Seiten
Humana Press (Verlag)
978-1-60761-561-3 (ISBN)

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Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole.  Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge.  In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors.  Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem.  An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions. 


Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.

1 Introduction to endocrine disruptors and Puberty  Evanthia Diamanti-Kandarakis  Andrea C. GorePart I: EDCs, endocrine systems, and puberty  2 In utero exposure to environmental chemicals - Lessons from maternal cigarette smoking and its effects on gonad development and puberty   Rebecca McKinlay  Peter O’Shaughnessey  Richard M. Sharpe  Paul A. Fowler3 Reproductive Neuroendocrine Targets of Developmental Exposure to Endocrine Disruptors   Sarah M. Dickerson  Stephanie L. Cunningham  Andrea C. Gore4 Endocrine disruptors and puberty disorders from mice to men (and women)   Alberto Mantovani5 Thyroid hormone regulation of mammalian reproductive development and the potential impact of endocrine disrupting chemicals  Kara Renee Thoemke  Thomas William Bastian  Grant Wesley AndersonPart II: Developmental exposure to endocrine disruptors and adverse reproductive outcomes  6 Developmental exposure to endocrine disruptors and ovarian function   Evanthia Diamanti-Kandarakis  Eleni Palioura  Eleni A.Kandaraki7 Developmental exposure to environmental endocrine disruptors and adverse effects on mammary gland development     Suzanne Fenton  Lydia M. Beck   Aditi R. Borde  Jennifer Rayner8 Developmental exposure to endocrine disruptors and male urogenital tract malformations   Mariana F. Fernandez  Nicolas Olea, MD PhD9 EDC exposures and the development of reproductive and non-reproductive behaviors   Amy B. Wisniewski  Craige C. Wrenn  Ashwini MallappaPart III. Developmental exposure to endocrine disruptors and metabolic disorders  10 Adipocytes as target cells for endocrine disruption   Amanda Janesick  Bruce Blumberg11 Altered Glucose Homeostasis Resulting From Developmental Exposures To Endocrine Disruptors  Alan Schneyer  Melissa Brown12 Developmental Exposure to Endocrine Disrupting Chemicals: Is there a Connection with Birth and Childhood Weights?     Elizabeth E. Hatch  Jessica W Nelson  Rebecca Triosi  Linda TitusPart IV. EDCs and Human Health  13 The Impact Of Endocrine Disruptors On Female Pubertal Timing  Jean-Pierre Bourguignon  Anne-Simone Parent14 The influence of endocrine disruptors on Male Pubertal Timing   Xiu-feng Wu  Ningning ZhangMary M. Lee15 Secular Trends in Pubertal Timing: A Role for Environmental Chemical Exposure?  Vincent F. Garry  Peter Truran, PhD

Erscheint lt. Verlag 1.12.2011
Reihe/Serie Contemporary Endocrinology
Contemporary Endocrinology
Zusatzinfo XVIII, 378 p.
Verlagsort Totowa
Sprache englisch
Themenwelt Medizinische Fachgebiete Innere Medizin Endokrinologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Naturwissenschaften Biologie Zellbiologie
Technik
Schlagworte Adipocyte • Birth weight • Body weight • Breast development • Childhood • Development • endocrine disruption • Endocrine disruption and Male:Female Ratio • Endocrine disruption and population risk • Endocrine disruption and public health • endocrine disruptors • Enviromental • Mammary Gland • Metabolism • Neuroendocrine HPG • Ovarian function • Pancreatic function • polychlorinated biphenyls • premature • Prostate • puberty • Puberty timing • Reproductive tract abnormalities • Testicular development • Thyroid dysregulation • Urogenital tract malformation
ISBN-10 1-60761-561-4 / 1607615614
ISBN-13 978-1-60761-561-3 / 9781607615613
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