Behavioral Neuroscience of Drug Addiction

David W. Self, Julie K. Staley Gottschalk (Herausgeber)

Buch | Softcover

XIV, 392 Seiten

2012 | 2010
Springer Berlin (Verlag)
978-3-642-26148-0 (ISBN)

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Drug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal dev- tation. The disorder af?icts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain's natural reward substrates, and that chronic drug use causes aberrant alterations in these rewa- processing systems. Such aberrations may be demonstrated at the cellular, neu- transmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chronic drug exposure. Behaviorally, these neural aberrations manifest as exaggerated, altered or dysfunctional expr- sion of learned behavioral responses related to the pursuit of drug rewards, or to environmental factors that precipitate craving and relapse during periods of drug withdrawal. Current research efforts are aimed at understanding the associative and causal relationships between these neurobiological and behavioral events, such that treatment options will ultimately employ therapeutic amelioration of neural de?cits and restoration of normal brain processing to promote efforts to abstain from further drug use. The Behavioral Neuroscience of Drug Addiction, part of the Springer series on Current Topics in Behavioral Neurosciences, contains scholarly reviews by noted experts on multiple topics from both basic and clinical neuroscience ?elds.

Preclinical Neuroscience.- Neuroplastic Alterations in the Limbic System Following Cocaine or Alcohol Exposure. Dopamine Signaling in the Nucleus Accumbens of Animals Self-Administering Drugs of Abuse. Amygdala Mechanisms of Pavlovian Psychostimulant Conditioning and Relapse. Prefrontal Cortical Regulation of Drug Seeking in Animal Models of Drug Relapse. Neural Substrates of Psychostimulant Withdrawal-Induced Anhedonia. Sensitization Processes in Drug Addiction.- Clinical Neuroscience.- Imaging Receptor Changes in Human Drug Abusers. Imaging Neurotransmitter Release by Drugs of Abuse. Imaging Cognitive Deficits in Drug Abuse. Neural Markers of Genetic Vulnerability to Drug Addiction. The Role of Executive Control in Human Drug Addiction. Behavioral Neuroeconomics of Drug Dependence. Novel Pharmacological Approaches to Drug Abuse Treatment.

Erscheint lt. Verlag	14.3.2012
Reihe/Serie	Current Topics in Behavioral Neurosciences
Zusatzinfo	XIV, 392 p. 26 illus., 5 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	613 g
Themenwelt	Medizin / Pharmazie ► Studium
Themenwelt	Naturwissenschaften ► Biologie ► Humanbiologie
Schlagworte	addiction • Behavior • behavioral neuroscience • Cocaine • craving • dopamine • Drogenabhängigkeit • drugs of abuse • Neurobiology • neuroimaging • Neuroscience • Neurowissenschaft
ISBN-10	3-642-26148-5 / 3642261485
ISBN-13	978-3-642-26148-0 / 9783642261480
Zustand	Neuware